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ProteomicsChemical phosphoproteomics sheds new light on the targets and modes of action of AKT inhibitors
Due to its important roles in oncogenic signaling, AKT has been subject to extensive drug discovery efforts leading to small molecule inhibitors investigated in advanced clinical trials. To better understand how these drugs exert their therapeutic effects at the molecular level, we combined chemopro...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD021836 | Pride
Kinobeads Akt inhibitor Phosphoproteomics 
ProteomicsKinase inhibition sensitizes pancreatic cancer cells towards radiation
Pancreatic ductal adenocarcinoma is one of the most aggressive cancer types and is well-known for its general low intrinsic radiosensitivity. In order to resolve mechanisms of how PDAC cells carry out radioresistance, a combination of proteomics and phosphoproteomics of two radiosensitive as well as...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-13 | PXD015284 | Pride
Pdac Phosphoproteomics Pancreatic cancer 
ProteomicsLARGE2 mediates O-glycosylation in HT-29 colorectal cancer cells
The O-glycosyltransferase LARGE2 attaches a laminin-binding matriglycan structure on alpha-Dystroglycan (α-DG) to mediate the interaction of different cell types with their laminin-containing basement membrane. We used HT-29 CRC cells, characterized by low endogenous LARGE2 gene expression, to ectop...
ORGANISM(S): Homo sapiens (Human) 
2020-06-28 | PXD013800 | Pride
Human O-glycosylation Colorectal cancer 
ProteomicsStress enhances secretory autophagy increasing extracellular Bdnf maturation
Stress response is a fundamental mechanism to maintain a healthy homeostasis and its disruption is implicated in several psychiatric disorders. Autophagy is one of the mechanisms regulating homeostasis, and it is known to be activated by cellular stressors such as starvation. In a previous study, w...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-05 | PXD017076 | Pride
Secretory autophagy Stress Secretome 
ProteomicsChemical and phosphoproteomics illuminate the cellular mode of action of AKT inhibitors
Due to its key role in dysregulated cellular signaling in cancer, AKT has been subject to intense drug discovery efforts leading to small molecule inhibitors investigated in clinical trials, notably breast cancer. To shed more light on how these drugs exert their therapeutic effects, we integrated c...
ORGANISM(S): Homo Sapiens 
2022-01-21 | PXD015188 | panorama
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