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UnknownSocioeconomic status and lung cancer: unraveling the contribution of genetic admixture.

Objectives

We examined the relationship between genetic ancestry, socioeconomic status (SES), and lung cancer among African Americans and Latinos.

Methods

We evaluated SES and genetic ancestry in a Northern California lung cancer case-control study (1998-2003) of African Americans and...
S-EPMC3780736 | biostudies-literature
GenomicsJ_Costello_20150506_dataset - samples
Dataset contains Exome-seq and RNA-seq from 2 GBM patients, as well as RNA-seq from the derived cultured cells (GNS).
EGAD00001001359 | EGA
GenomicsThe transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, fundamental steps in the initiation of human cancer. Multiple cancer types, including up to 83% of glioblastomas (GBM), harbor highly recurrent TERT promoter mut...
EGAS00001001242 | EGA
GenomicsGlioma GWAS summary statistics
Meta-analysis association statistics from case-control analysis (includes imputed SNPs)
EGAD00010001657 | EGA
GenomicsSummary statistics from genome-wide association study in glioma of 12,488 cases and 18,169 controls.
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,488 cases and 18,169 controls. We identified five ...
EGAS00001003372 | EGA
GenomicsGlioma GWAS summary statistics DAC
Data Access Committee EGAC00001001116
EGAC00001001116 | EGA
GenomicsCohort-Based Genome-Wide Association Study of Glioma (GliomaScan)

We conducted a new independent GWAS of adult glioma using 1,856 cases and 4,955 controls from 14 cohort studies belonging to the Cohort Consortium, 3 case-control studies, and 1 population-based case only study. Cases were newly diagnosed glioma [ICDO-3 codes 9380-9480 or equivalent], and control...

phs000652.v1.p1 | EGA
UnknownGenome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.
Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and mortality rates among different ethnic groups in the United States. Non-Hispanic African Americans had a high incidence rate of lung cancer at 55.8 per 100 000 people, as well as the highest death rate...
S-EPMC12407114 | biostudies-literature
UnknownThe landscape of recombination in African Americans.
Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 m...
S-EPMC3154982 | biostudies-literature
UnknownA meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up t...
S-EPMC3694490 | biostudies-literature
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