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TranscriptomicsGlucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
Some T's in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (?-D-glucosyl-hydroxymethyluracil). In Leishmania about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA Polymerase II ter...
ORGANISM(S): Leishmania major 
2011-10-15 | E-GEOD-32976 | biostudies-arrayexpress
ProteomicsWild-type and Pgrmc1 KO mouse liver membrane LC-MSMS with isobaric tagging
Progesterone receptor membrane component 1 (PGRMC1) is a heme binding protein implicated in a wide range of cellular functions. Our previous studies showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and promotes activity of these enzymes. Recently, the paralog PGRMC2 was show...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD028238 | Pride
Lc-msms Mouse Tmt Membrane Pgrmc1 Liver Isobaric tag 
UnknownTargeting Mdmx to treat breast cancers with wild-type p53.
Not available
S-EPMC4650725 | biostudies-literature
ProteomicsLC-MSMS with isobaric tagging on Flag-coimmunoprecipitation eluates from Flag-Pgrmc1 and Y113F Flag-Pgrmc1 expressing Pgrmc1 KO mouse liver membranes
Progesterone receptor membrane component 1 (PGRMC1) is a heme binding protein implicated in a wide range of cellular functions. Our previous studies showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and promotes activity of these enzymes. Recently, the paralog PGRMC2 was show...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028284 | Pride
Lc-msms Mouse Tmt Co-immunoprecipitation Y113f flag-pgrmc1 Bound Membrane Pgrmc1 Flag-pgrmc1 Liver Eluate Isobaric tag 
ProteomicsLC-MSMS with isobaric tagging of Pgrmc1 KO mouse liver membranes expressing Flag-Pgrmc1 or Y113F Flag-Pgrmc1
Progesterone receptor membrane component 1 (PGRMC1) is a heme binding protein implicated in a wide range of cellular functions. Our previous studies showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and promotes activity of these enzymes. Recently, the paralog PGRMC2 was show...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD028288 | Pride
Lc-msms Mouse Tmt Y113f flag-pgrmc1 Membrane Pgrmc1 Flag-pgrmc1 Liver Isobaric tag 
ProteomicsCalu-3 cell lipidome response to a wild type H5N1 and mutants Influenza viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H5N1 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-04 | MSV000080023 | MassIVE
ProteomicsMouse lung metabolome response to a wild type infectious clone of H7N9 Influenza virus and mutants
Metabolomics data from mouse lung; Treated with wild-type and mutant H7N9 and mockulum; Time points 1, 2, 4 & 7 days; 5 biological replicates
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-07-31 | MSV000079206 | MassIVE
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.
Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress
ProteomicsHuman Calu-3 cell lipidome response to a wild type infectious clone of H7N9 and mutant H7N9 viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H7N9 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-11-23 | MSV000079386 | MassIVE
ProteomicsHuman Calu-3 cell proteome response to a wild type infectious clone of H5N1 and mutant H5N1 viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H5N1 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-01-18 | MSV000079459 | MassIVE
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