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ProteomicsLC-MSMS with isobaric tagging on Flag-coimmunoprecipitation eluates from Flag-Pgrmc1 and Y113F Flag-Pgrmc1 expressing Pgrmc1 KO mouse liver membranes
Progesterone receptor membrane component 1 (PGRMC1) is a heme binding protein implicated in a wide range of cellular functions. Our previous studies showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and promotes activity of these enzymes. Recently, the paralog PGRMC2 was show...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028284 | Pride
Lc-msms Mouse Tmt Co-immunoprecipitation Y113f flag-pgrmc1 Bound Membrane Pgrmc1 Flag-pgrmc1 Liver Eluate Isobaric tag 
ProteomicsLC-MSMS with isobaric tagging of Pgrmc1 KO mouse liver membranes expressing Flag-Pgrmc1 or Y113F Flag-Pgrmc1
Progesterone receptor membrane component 1 (PGRMC1) is a heme binding protein implicated in a wide range of cellular functions. Our previous studies showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and promotes activity of these enzymes. Recently, the paralog PGRMC2 was show...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD028288 | Pride
Lc-msms Mouse Tmt Y113f flag-pgrmc1 Membrane Pgrmc1 Flag-pgrmc1 Liver Isobaric tag 
ProteomicsProtein complexes between PGRMC1 and actin-associated proteins are disrupted by AG-205
PGRMC1 is a protein from the MAPR family with a range of cellular functions. PGRMC1 has been described to play a role in regulating membrane trafficking and in cancer progression and response to therapies. To further understand the functions of PGRMC1 and the mechanism of the small molecule inhibito...
ORGANISM(S): Homo sapiens (Human) 
2020-01-24 | PXD016455 | Pride
Ap-ms Cancer Pgrmc1 Trafficking 
TranscriptomicsEffects of PGRMC1 phosphorylation on genome integrity and epigenetics
Progesterone receptor membrane component 1 (PGRMC1) is a protein that has been implicated in cancer biology and poor patient outcomes, which can be over-expressed in cancers, and exist in alternative states of phosphorylation.Here, we show that manipulation of PGRMC1 phosphorylation by mutagenesis r...
ORGANISM(S): Homo sapiens 
2019-12-01 | E-MTAB-8218 | biostudies-arrayexpress
ProteomicsEffects of PGRMC1 phosphorylation status on MIA PaCa-2 cells
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. Multiple different functions and cellular locations have been attributed to PGRMC1 in a variety of contexts, however the mechanisms underlying PGRMC1 biolo...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD014716 | Pride
Proteomics Swath Phosphorylation Pancreatic cancer 
GenomicsQuantitative analysis of wild-type and Pgrmc1 knockout mouse liver transcriptomes
Quantitative analysis of wild-type and Pgrmc1 knockout mouse liver transcriptomes
PRJNA729646 | ENA
ProteomicsWild-type and Pgrmc1 KO mouse liver membrane LC-MSMS with isobaric tagging
Progesterone receptor membrane component 1 (PGRMC1) is a heme binding protein implicated in a wide range of cellular functions. Our previous studies showed that PGRMC1 binds to cytochromes P450 in yeast and mammalian cells and promotes activity of these enzymes. Recently, the paralog PGRMC2 was show...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD028238 | Pride
Lc-msms Mouse Tmt Membrane Pgrmc1 Liver Isobaric tag 
ProteomicsPGRMC1 is a novel potential tumor biomarker of human renal cell carcinoma based on quantitative proteomics and integrative biological assessments
Progesterone receptor membrane component 1 (PGRMC1) is widely observed at elevated expression levels in multiple human cancers. However, the associations of PGRMC1 with renal cancer are not clear and merit further study. In this report, we report a systematic, integrative biological assessment of PG...
ORGANISM(S): Homo sapiens (Human) 
2017-01-24 | PXD004595 | Pride
Pgrmc1 Renal cell carcinoma Upregulation Quantitative proteomics 
TranscriptomicsQuantitative analysis of wild-type and Pgrmc1 knockout mouse liver transcriptomes
The goal of this study is to compare the next generation sequencing-derived liver transcriptome of Pgrmc1 KO mice to wild-type controls to identify differentially expressed genes.
ORGANISM(S): Mus musculus 
2021-11-24 | GSE174375 | GEO
ProteomicsPGRMC1 promotes progestin-dependent proliferation of breast cancer cells by binding prohibitins resulting in activation of ERα signaling
Combined menopausal hormone therapy is associated with increased breast cancer risk in postmenopausal women. In our previous studies, progesterone receptor membrane component 1 (PGRMC1) was shown to play a role in progestins’ mode of action, resulting in enhanced proliferation of breast cancer cells...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028537 | Pride
Breast cancer Phb2 Pgrmc1 Progesterone Estrogen receptor Progestins Hormone therapy Phb1 
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