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ProteomicsLarge scale screens of small molecules using multiple sources of human acute leukemia cells reveal novel targeting strategies
Useful targeted therapeutics for high risk subgroups of acute leukemia remain an unmet medical need. Here we report the results of a large-scale screening strategy that tested thousands of compounds targeting many signalling pathways for their ability to inhibit the survival and growth in vitro of h...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD040772 | Pride
Acute leukemia 
UnknownImmunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.
Not available
S-EPMC10694946 | biostudies-literature
UnknownThe BCR-ABL inhibitor nilotinib influences phenotype and function of monocyte-derived human dendritic cells.
Not available
S-EPMC11028318 | biostudies-literature
UnknownStaphylococcus epidermidis Bacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways.
Not available
S-EPMC4601917 | biostudies-literature
UnknownFine tuning of the side-to-side tenorrhaphy: A biomechanical study assessing different side-to-side suture techniques in a porcine tendon model.
Not available
S-EPMC8491917 | biostudies-literature
UnknownSex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians.
Not available
S-EPMC5839119 | biostudies-literature
ProteomicsTargeted degradation of the enhancer lysine acetyltransferases CBP and p300
The enhancer factors CBP/p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional regulators and by scaffolding functions mediated by several protein-protein interaction domains. We have designed dCBP-1, a compound that induces degradation of CBP/p300, and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-15 | MSV000086457 | MassIVE
MetabolomicsGrowth Substrate and Prophage Induction Collectively Influence Metabolite and Lipid Profiles in a Marine Bacterium

Bacterial growth substrates influence a variety of biological functions, including the biosynthesis and regulation of lipid intermediates. The extent of this rewiring is not well understood nor has it been considered in the context of virally-infected cells. Here, we use a one-host-two-temperate ...

2022-08-04 | MTBLS5345 | MetaboLights
UnknownGWAS meta-analysis identifies five susceptibility loci for endometrial cancer.
Not available
S-EPMC12275056 | biostudies-literature
UnknownCD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.
Not available
S-EPMC4941145 | biostudies-literature
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