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UnknownTetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners.
Not available
S-EPMC4705661 | biostudies-literature
TranscriptomicsGenome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations [RNA-seq]
Nonsense-mediated mRNA decay (NMD) surveillance pathways are best known to be involved in the degradation of mRNA with premature termination codons (PTCs). More recent studies demonstrate that the role of NMD pathways goes well beyond the degradation of PTC containing mRNA, into the regulation of ce...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27199 | biostudies-arrayexpress
GenomicsRUNX1 is a key target gene in t(4;11) leukemias and contributes to gene activation by interacting with the AF4-MLL complex
The Mixed Lineage Leukemia 1 protein (MLL1) is an important epigenetic regulator required for the maintenance of gene activation during development. MLL1 chromosome translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL1 fusion proteins have distinct l...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-42075 | biostudies-arrayexpress
UnknownSMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis.
Not available
S-EPMC9723633 | biostudies-literature
TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
UnknownDNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis.
Not available
S-EPMC3327359 | biostudies-literature
ProteomicsSmg6 interacting partners in mouse
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential for male germ cell differentiation in mice. Germ-cell conditional knockout (cKO) of Smg6 induces extensive transcriptome misregulatio...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-01 | PXD037090 | Pride
Smg7 Chromatoid body Mouse Smg6 
GenomicsThe Genomic Complexity of Primary Human Prostate Cancer

Seven primary prostate cancers and their paired normal counterparts were DNA-sequenced on a massively parallel sequencing platform. This approach was taken to investigate the genomes for mutations and genomic alterations that would be undetectable by lower-resolution methods. As result, tumor...

phs000330.v1.p1 | EGA
TranscriptomicsMyeloid Dendritic Cells Induce HIV-1 Latency in Non-Proliferating CD4+ T Cells
Latently infected resting CD4+ T cells are a major barrier to HIV cure. Understanding how latency is established, maintained and reversed is critical to identifying novel strategies to eliminate latently infected cells. We demonstrate here that co-culture of resting CD4+ T cells and syngeneic myeloi...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-52344 | biostudies-arrayexpress
GenomicsProstate Cancer Genome Sequencing Project

Prostate cancer is a prevalent cause of cancer morbidity and mortality in men. In order to characterize the full range of somatic mutations in protein-coding genes that may drive the growth of prostate cancer, we sequenced the exonic regions of genomic and tumor DNA from over 100 patients with hi...

phs000447.v1.p1 | EGA
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