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TranscriptomicsmRNA-Seq from control cells and two clones of Flp-In-T-REx-293 cells modified via CRISPR-Cas9 to knockout SMG7 in combination to knockdowns of control, SMG5, and SMG6
Mature mRNAs undergo quality control during translation that may lead to RNA degradation by triggering the nonsense mediated decay (NMD) pathway. Aberrant translation due to features such as the presence of a premature stop codon downstream on an exon-exon junction or an intron in the 3'UTR activate...
ORGANISM(S): Homo sapiens 
2021-05-07 | E-MTAB-9330 | biostudies-arrayexpress
ProteomicsNonsense-mediated mRNA decay relies on "two-factor authentication" by SMG5-SMG7
Eukaryotic gene expression is constantly regulated and controlled by the translation-coupled nonsense-mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD activation and robust clearance of NMD targets via two seemingly independent and redundant mRNA degradation branches....
ORGANISM(S): Homo sapiens (Human) 
2021-05-08 | PXD024747 | Pride
Smg6 Mrna degradation Gene expression Smg5-smg7 Nonsense-mediated mrna decay Upf1 
ProteomicsA SMG7-eIF4A module constitutes a homeostatic system for P-bodies and Meiotic bodies
The nucleation of RNP granules requires the participation of mRNAs, which simultaneously as becoming their target, dictate their properties. Here we report that in Arabidopsis the RNA helicase eIF4A limits the condensation of P-bodies acting as an RNA chaperone, disassembled from the eIF4F complex. ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-03-25 | PXD061406 | Pride
Eif4a Stress granules P-bodies Eif4f Rnp granules Biomolecular condensates Smg7 Rna condensation Meiosis Meiotic bodies 
UnknownUPF1/SMG7-dependent microRNA-mediated gene regulation.
Not available
S-EPMC6744440 | biostudies-literature
UnknownFunctional Characterization of SMG7 Paralogs in Arabidopsis thaliana.
Not available
S-EPMC6232500 | biostudies-literature
TranscriptomicsGenome-wide analysis of Human Upf1, SMG5, SMG7 and PNRC2 downregulated substrates in HeLa cell
Analysis of cellular NMD (Nonsense-mediated mRNA decay) substrates that regulated by Upf1, SMG5, SMG7 and/or PNRC2 in HeLa cell. The hypothesis tested in the present study was that endogenous NMD substrates may co-regulated by Upf1, SMG5, SMG7 and PNRC2.
ORGANISM(S): Homo sapiens 
2012-11-01 | GSE34876 | GEO
UnknownSMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.
Not available
S-EPMC8233366 | biostudies-literature
UnknownDecreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production.
Not available
S-EPMC4949149 | biostudies-literature
UnknownSMG7 is a critical regulator of p53 stability and function in DNA damage stress response.
Not available
S-EPMC4860962 | biostudies-literature
UnknownA CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis.
Not available
S-EPMC8509889 | biostudies-literature
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