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TranscriptomicsInterplay between AP-1 and ERalpha in regulating gene expression and proliferation networks in breast cancer cells
Estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERalpha can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interaction...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36586 | biostudies-arrayexpress
no omics definedTranscription profiling of breast cancer cells with TET-OFF regulated ERb expression treated with estradiol or ICI, an estrogen receptor antagonist
Assess the full impact of estrogen receptor beta on transcription by a full transcriptome analysis of ERa and ERb-mediated gene regulation in T47D breast cancer cell line with TET-OFF regulated ERb expression.
ORGANISM(S): Homo sapiens 
2007-12-17 | E-MEXP-969 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreatic buds from wild type and Ipf1/Pdx1 knock-out mouse embryos
Identification of genes regulated by IPF1/PDX1 in early pancreatic progenitor cells, analysis of Ipf1/Pdx1 global null mutants e10.5 embryonic pancreatic buds compared to wt
ORGANISM(S): Mus musculus 
2008-02-12 | E-MEXP-1047 | biostudies-arrayexpress
TranscriptomicsGenome-wide effects of the maternal embryonic leucine zipper kinase (MELK) in triple-negative breast cancer cells indicate context-dependent effects and p53 as a key determinant
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-68693 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 48h Treatment with OTSSP167 MELK Inhibitor vs. DMSO Control
Microarray comparing TNBC cells treated for 48 hours with OTSSp167 MELK Inhibitor and control (DMSO) Two-condition arrays: MDA-MB-231 cells were treated with either 4.5nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 48h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-68652 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 45nM OTSSP167 MELK Inhibitor vs. DMSO Control
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: MDA-MB-231 cells were treated with either 45nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-68692 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 4.5nM OTSSP167 MELK Inhibitor vs. DMSO Control
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: MDA-MB-231 cells were treated with either 4.5nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-68691 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 4.5nM OTSSP167 MELK Inhibitor vs. DMSO Control (SUM159)
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: SUM159 cells were treated with either 4.5nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-71026 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 45nM OTSSP167 MELK Inhibitor vs. DMSO Control (SUM159)
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: SUM159 cells were treated with either 45nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-71027 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse epithelial cell line HC11which have stem cell characteristics during stem cell differentiation
In this study we have used a murine mammary epithelial cell line (HC11) with stem cell characteristics and made a thorough investigation of global gene-expression changes during mammary stem cell differentiation.
ORGANISM(S): Mus musculus 
2009-09-18 | E-MEXP-1809 | biostudies-arrayexpress
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