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ModelsReddyhoff2015 - Acetaminophen metabolism and toxicity
Reddyhoff2015 - Acetaminophen metabolism and toxicity This model examines acetaminophen metabolism and related hepatotoxicity. Multiple pathways associated with APAP metabolism has been included in the model. Using numerical, sensitivity and timescale analysis, key parameters invo...
2024-09-02 | BIOMD0000000609 | BioModels
TranscriptomicsComparative genomic hybridization of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel
Array comparative genomic hybridization characterization and comparison of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel.
ORGANISM(S): Homo sapiens 
2005-11-23 | E-TABM-65 | biostudies-arrayexpress
TranscriptomicsBlood RNA sequencing was performed on a cohort of adults attending the Emergency Department with suspected infection who had subsequently-confirmed viral, bacterial, or no infection diagnoses
The cohort comprised patients recruited between August 2014 - April 2017. It includes patients with bacteremia, positive viral diagnostic test in the context of acute admission and those with no positive microbial diagnostic test, no infection-related ICD-10 diagnostic codes, and no empirical antivi...
ORGANISM(S): Homo sapiens 
2021-08-11 | E-MTAB-10527 | biostudies-arrayexpress
TranscriptomicsChromatin immunopreciptiation of mouse hepatocytes to validate deep-sequencing libraries
Chromatin immunoprecipitation followed by ultra-high throughput (UHTP) sequencing (ChIP-seq) is a powerful tool to establish protein-DNA interactions genome-wide, and the primary limitation of its broad application at present is the often-limited access to sequencers. Here, we report a protocol, Mab...
ORGANISM(S): Mus musculus 
2008-06-11 | E-TABM-485 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration
Effect of vehicle vs non-toxic and toxic paracetamol (151mg/kg and 529mg/kg) doses on the gene expression profile at 1, 4 and 24h in murine liver.
ORGANISM(S): Mus musculus 
2004-02-20 | E-MEXP-82 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of white adipose tissue in eight week old Insulin Receptor Substrate-2 (IRS-2) knock out mice
Mice which lack IRS-2, develop insulin resistance. Comparison between white adipose tissue from 8 week old IRS-2 KO and wild type mice. Processed data is not included for this experiment and therefore these data are not MIAME compliant
ORGANISM(S): Mus musculus 
2012-01-01 | E-BAIR-2 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of white adipose tissue in five week old Insulin Receptor Substrate-2 (IRS-2) mice
Mice which lack IRS-2, develop insulin resistance. Comparison between white adipose tissue from 5 week old IRS-2 KO and wild type mice. Processed data is not included for this experiment and therefore these data are not MIAME compliant
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-1 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver tissue from humans, wild type mice and a Down syndrome mouse model containing human chromosome 21 to determine whether genetic sequence or nuclear enviornment directs tissue-specific transcription factor binding
Homologous sets of transcription factors direct conserved tissue-specific transcription, yet transcription factor binding events diverge rapidly between closely related species. We used hepatocytes from a Down syndrome mouse model containing human chromosome 21 (TC1) to determine whether human gene...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-473 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver with CEBPa wild type and knockout animals.
Expression analysis of CEBPa knockout effects on gene expression in adult mouse liver. We used a conditional knock out strategy to delete CEBPa specifically in adult mouse hepatocytes and analysed the resulting changes in gene expression by means of microarrays.
ORGANISM(S): Mus musculus 
2010-04-08 | E-MTAB-178 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of liver tissue from humans, wild type mice and a Down syndrome mouse model containing human chromosome 21 to determine where genetic sequence or nuclear environment directs tissue specific-specific transcription factor binding
Homologous sets of transcription factors direct conserved tissue-specific transcription, yet transcription factor binding events diverge rapidly between closely related species. We used hepatocytes from a Down syndrome mouse model containing human chromosome 21 to determine whether human genetic se...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-474 | biostudies-arrayexpress
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