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TranscriptomicsTranscription profiling of human lung adenocarcinoma A549 cells treated with vehicle (DMSO) or Etoposide (ETOP, 10 uM ), Benzo(a)pyrene Cryptolepineand 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine for 6 h, 16 h, 24 h, 48 h and 72 h
Title: Prediction of cell cycle behaviour in response to DNA damage agents via transcriptomic approach
Description: Human lung adenocarcinoma A549 cells were treated with vehicle (DMSO) or Etoposide (ETOP, 10 M-BM-5M ), Benzo(a)pyrene (BaP, 25 M-BM-5M ), Cryptolepine ( CLP, 2.5 M-BM-5M) and 2...
ORGANISM(S): Homo sapiens 
2006-06-01 | E-MIMR-102 | biostudies-arrayexpress
TranscriptomicssiRNA of human MCF-7 cells
Overexpression of the AP-2γ transcription factor in breast tumours has been identified as an independent predictor of poor outcome and failure of hormone therapy, even in ER positive, ErbB2 negative tumours; markers of a more favourable prognosis. To understand further the role of AP-2γ in breast...
ORGANISM(S): Homo sapiens 
2009-12-19 | E-GEOD-15481 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
TranscriptomicsTranscription profiling of Drosophila samples of wild type, aly, can, zaa and zab testes
Drosophila melanogaster males mutant for any meiotic arrest gene have defective spermatogenesis, with cells arresting as primary spermatocytes, and failing to progress to later stages. This phenotype is remarkably similar to meiosis I maturation arrest azoospemia in humans. Drosophila meiotic arrest...
ORGANISM(S): Drosophila melanogaster 
2004-05-07 | E-FLYC-5 | biostudies-arrayexpress
TranscriptomicsThe innate and adaptive immune response to BCG stimulation in splenocytes taken from C57BL/6 mice
The aim of this experiment was to investigate differential gene expression in splenocytes stimulated with BCG from naïve and BCG vaccinated mice. The differences between naïve and BCG vaccinated mice might indicate the mechanisms by which BCG vaccination confers an enhanced ability of splenocytes fr...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-42090 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse H-2Kb muscle cells treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours
The basic design of the experiment is as described in Fryer et al.(2000)Diabetes 49:1978, and is similar to proto-BAIR (EXP_BAIR_0603_02). H-2Kb muscle cells were treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours.
ORGANISM(S): Mus musculus 
2022-11-23 | E-BAIR-7 | biostudies-arrayexpress
TranscriptomicsWidespread transcriptional changes preempt the critical pelagic-benthic transition in the vetigastropod Haliotis asinina
Larval settlement and metamorphosis is a vital transition period for marine invertebrates and can have far-reaching effects on the ecology and evolution of a species. To explore the molecular mechanisms of this critical process in a non-model organism, the tropical abalone Haliotis asinina, we emplo...
ORGANISM(S): Haliotis asinina 
2010-05-19 | E-GEOD-13039 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human post-mortem conjunctivae and corneal epithelia
Whole human conjunctivae and human corneas were obtained from the National Disease Research Interchange (NDRI, Philadelphia, PA) and processed between 48 - 72 hr of death. No donor details apart from age, sex and cause of death were released. Criteria for inclusion were donor ages between 25 - 65 ye...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-5543 | biostudies-arrayexpress
UnknownCan Automated Hematology Analyzers Predict the Presence of a Genetic Hemoglobinopathy? An Analysis of Hematological Biomarkers in Cambodian Women.
Not available
S-EPMC7913495 | biostudies-literature
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