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Transcriptomics7q11.23 dosage-dependent dysregulation in the human pluripotent state primes aberrant transcriptional programs in disease-relevant lineages (microarray)
We apply the cellular reprogramming experimental paradigm to two disorders caused by symmetrical copy number variations (CNV) of 7q11.23 and displaying a striking combination of shared as well as symmetrically opposite phenotypes: Williams Beuren syndrome (WBS) and 7q microduplication syndrome (7dup...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-63040 | biostudies-arrayexpress
MetabolomicsStable Isotope–Assisted Plant Metabolomics: Combination of Global and Tracer-Based Labeling for Enhanced Untargeted Profiling and Compound Annotation
Untargeted approaches and thus biological interpretation of metabolomics results are still hampered by the reliable assignment of the global metabolome as well as classification and (putative) identification of metabolites. In this work we present an liquid chromatography-mass spectrometry (LC-MS)-b...
2020-02-09 | MTBLS1217 | MetaboLights
UnknownTelehealth personalized cancer risk communication to motivate colonoscopy in relatives of patients with colorectal cancer: the family CARE Randomized controlled trial.
Not available
S-EPMC3927734 | biostudies-literature
UnknownPubertal Escape From Estradiol Negative Feedback in Ewe Lambs Is Not Accounted for by Decreased ESR1 mRNA or Protein in Kisspeptin Neurons.
Not available
S-EPMC5761595 | biostudies-literature
TranscriptomicsRNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome
Using a targeted Gtf2ird1 knockout mouse, we employed massively-parallel sequencing of mRNA (RNA-Seq) to understand changes in the transcriptional landscape associated with inactivation of Gtf2ird1 in lip tissue. We found widespread dysregulation of genes including differential expression of 78 tran...
ORGANISM(S): Mus musculus 
2016-08-03 | E-GEOD-81082 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsS100A8/A9 activate key genes and pathways in colon tumor progression
Studies using bone marrow chimeric mice revealed that S100A8/A9 expression on myeloid cells is essential for development of colon tumors. Our results thus reveal a novel role for myeloid-derived S100A8/A9 in activating specific downstream genes associated with tumorigenesis and in promoting tumor gr...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-26359 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of Leishmania infantum methotrexate resistant strains using full-genome DNA microarrays
Transcriptional analysis of the drug resistant strain L. infantum MTX20.5 compared to the wild-type strain The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L. infantum Keywords: drug resistance Two-condition experiment, resistant strain MTX20.5 vs wild-type. Fo...
ORGANISM(S): Leishmania infantum 
2010-05-25 | E-GEOD-9947 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of Leishmania major methotrexate resistant strains using full-genome DNA microarrays
Transcriptional analysis of the drug resistant strain L. major MTX60.4 compared to the wild-type strain LV39 The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L.major LV39 Keywords: drug resistance Two-condition experiment, resistant strain MTX60.4 vs wild-type ...
ORGANISM(S): Leishmania major 
2010-05-25 | E-GEOD-9948 | biostudies-arrayexpress
ProteomicsH3K79 methyltransferase Dot1p/DOT1L is phosphorylated by proline-directed MAP kinases Hog1p and p38/MAPK11
Disruptor of telomeric silencing (Dot1p) is an exquisitely conserved histone methyltransferase, and is the sole enzyme responsible for H3K79 methylation in the budding yeast, Saccharomyces cerevisiae. It has been shown to be highly phosphorylated in vivo; however, the upstream kinases that act on Do...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2024-01-29 | PXD036747 | Pride
Yeast Signalling Post-translational regulation Histone methylation Epigenetics Chromatin 
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