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TranscriptomicsTranscription profiling of FNR transcriptional regulator and NarP response regulator knock-out strains of Neisseria gonorrhoeae
Knock out mutants of FNR transcriptional regulator (NGO1579) and NarP response regulator (NGO0752) in N. gonorrhoeae compared to parent strain grown in liquid culture.
ORGANISM(S): Neisseria gonorrhoeae 
2006-08-15 | E-MEXP-726 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of two transgenic models familial hypertrophic cardiomyopathy mice vs wild type and non transgenic controls using pooled and non pooled heart extracts to identify differences in gene expression in FHC
Familial hypertrophic cardiomyopathy (FHC) is a disease characterized by ventricular hypertrophy, fibrosis, and aberrant systolic and/or diastolic function. We previously developed two transgenic mouse models that carry FHC associated mutations in alpha-tropomyosin (TM): FHC alpha-TM175 mice show pa...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4678 | biostudies-arrayexpress
TranscriptomicsPulmonary retention of titanium dioxide nanoparticles and biological outcomes following low dose instillation in mice
Pulmonary exposure to high doses of nanoparticles (NP) leads to well characterized lung toxicity in addition to long-term NP retention. However, pulmonary NP accumulation and toxicity following low dose exposures are not well described. In the present study we sought to: (1) investigate particle ret...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-41041 | biostudies-arrayexpress
TranscriptomicsEffect of Titanium dioxide nanoparticles on Escherichia coli K12 MG1655 genes expression
In the present study, we investigated the transcriptional expression patterns of the model strain E. coli exposed to titanium dioxide nanoparticles (NP-TiO2), under dark conditions by using a microarray. Expression profiles were compared to unexposed E.coli and ratio of expression were analysed. Cel...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-09-08 | E-GEOD-55972 | biostudies-arrayexpress
TranscriptomicsComprehensive expression analysis of primary hepatocytes under four different culture conditions
Primary hepatocytes have been widely explored as cell sources for the study of in vitro drug metabolism and pharmacokinetics (DMPK). Aiming toward establishing an in vitro drug screening method, the current study illustrated a comprehensive increase in the DMPK-related gene expression of nanopillar ...
ORGANISM(S): Rattus norvegicus 
2015-06-25 | E-GEOD-38950 | biostudies-arrayexpress
UnknownEfficacy of intrathecal mesenchymal stem cell-neural progenitor therapy in progressive MS: results from a phase II, randomized, placebo-controlled clinical trial.
Not available
S-EPMC11119709 | biostudies-literature
UnknownDiels-Alder reactions of five-membered heterocycles containing one heteroatom.
Not available
S-EPMC4378267 | biostudies-literature
TranscriptomicsIntratracheally Instilled Titanium Dioxide Nanoparticles Translocate to Heart and liver and Activate Complement Cascade in the Heart of C57BL/6 Mice (Liver)
An estimated 1% or less of the nanoparticles (NPs) deposited in lungs translocate to systemic circulation and enter other organs; however this estimation may not be accurate considering the low sensitivity of the existing in vivo NP detection methods. Moreover, the biological outcomes of such low le...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-56325 | biostudies-arrayexpress
TranscriptomicsIntratracheally Instilled Titanium Dioxide Nanoparticles Translocate to Heart and liver and Activate Complement Cascade in the Heart of C57BL/6 Mice (Heart)
An estimated 1% or less of the nanoparticles (NPs) deposited in lungs translocate to systemic circulation and enter other organs; however this estimation may not be accurate considering the low sensitivity of the existing in vivo NP detection methods. Moreover, the biological outcomes of such low le...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-56324 | biostudies-arrayexpress
TranscriptomicsFMR1 targets distinct mRNA sequence elements to regulate protein expression [Affymetrix]
Fragile-X Syndrome (FXS) is a multi-organ disease leading to mental retardation, macro-orchidism in males, and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASD). FXS is typically caused by the loss of FRAGILE...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-39504 | biostudies-arrayexpress
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