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ModelsReddyhoff2015 - Acetaminophen metabolism and toxicity
Reddyhoff2015 - Acetaminophen metabolism and toxicity This model examines acetaminophen metabolism and related hepatotoxicity. Multiple pathways associated with APAP metabolism has been included in the model. Using numerical, sensitivity and timescale analysis, key parameters invo...
2024-09-02 | BIOMD0000000609 | BioModels
TranscriptomicsAdvancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of response to selenite of yeast strains that are wild type or deleted for transcription factor encoding genes involved in stress responses
This work aimed at analysing the transcriptome response of S. cerevisiae strains, wild type or deleted for transcription factor encoding genes involved in stress response, to selenite (1mM), inoculated for different time periods.
ORGANISM(S): Saccharomyces cerevisiae 
2008-03-14 | E-TABM-439 | biostudies-arrayexpress
TranscriptomicsTempo-Seq experiment relating to Next Generation Risk Assessment for Occupational Chemical Safety – a Real World Example with Sodium-2-hydroxyethane sulfonate
A dose response and human cell line comparison of transcriptional responses following treatment with the chemical compound Sodium-2-hydroxyethane sulfonate. Gene expression changes were used to estimate the POD - minimum effect concentration when a biological perturbation as estimated by gene exp...
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-14069 | biostudies-arrayexpress
TranscriptomicsAre Non-animal Systemic Safety Assessments Protective: A Toolbox and Workflow
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15258 | biostudies-arrayexpress
TranscriptomicsAn Advancement in Developmental and Reproductive Toxicity (DART) Risk Assessment: Evaluation of a Bioactivity and Exposure-Based NAM Toolbox
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15274 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of the diazotrophic cyanobacterium C.watsonii WH 8501 during light-dark cycles
Whole-genome gene expression in the diazotrophic cyanobacterium C.watsonii WH 8501 during light/dark cycles
ORGANISM(S): Crocosphaera watsonii WH 8501 
2009-07-29 | E-TABM-737 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of yeast to identify Yap1p binding in response to hydrogen peroxide and selenite treatment
This work aimed at analysing the Yap1p genome-wide location in different physiological conditions.
ORGANISM(S): Saccharomyces cerevisiae 
2008-03-05 | E-TABM-437 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dermal microvascular endothelial, fibroblast, and glioblastoma cells treated with mycophenolic acid
The effect of Mycophenolic acid on primary isolated human dermal microvascular endothelial (HDMVEC) and fibroblast cells as well as human glioblastoma brain tumor cell line (U87).
ORGANISM(S): Homo sapiens 
2008-06-25 | E-TABM-315 | biostudies-arrayexpress
TranscriptomicsIGR_MACROPHAGE_MOUSE_MUTATION_CEA_PHR
Macrophage activation during the innate immune response is tightly regulated to prevent tissue damage while activating the defense to cellular attack. Using a mouse model where Trim33 is specifically deleted in mature myeloid cells, we show that TRIM33 is essential for two aspects of the inflammator...
ORGANISM(S): Mus musculus 
2015-06-30 | E-MTAB-1441 | biostudies-arrayexpress
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