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ProteomicsThe Prostacyclin Receptor is a NRF2-regulated Immune Checkpoint in CD8 T cells
Immune checkpoint inhibitor (ICI) therapies revitalize anti-cancer responses by intercepting protein-protein interactions between exhausted CD8 T (Tex) cells and cancer cells (e.g. PD-1:PD-L1). However, up to 50% of patients receiving ICIs relapse, warranting further interrogation of the underpinnin...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-25 | PXD052688 | Pride
Adoptive cell therapy T cell exhaustion Immune checkpoint 
TranscriptomicsCD8+/CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients
We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T-cell distribution and functions, and the prognosis significance of ...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-MTAB-3266 | biostudies-arrayexpress
Transcriptomics3' RNA-seq of flies over-expressing cabut protein or RNAi against cabut mRNA
CbtOE (Tim-gal4; UAS-cbtFLAG), Tim-gal4 (control for CbtOE), cbtRNAi (Tim-gal4-UAS-Dcr2-UAS-cbtIR-cbtE1) and Tim-gal4;UAS-Dcr2 (control for CbtRNAi) flies. Flies were entrained in LD (light: dark) condition for 3-4 days and harvested at six time points: ZT3, ZT7, ZT11, ZT15, ZT19, ZT23 Fly heads we...
ORGANISM(S): Drosophila melanogaster 
2015-05-08 | E-GEOD-67590 | biostudies-arrayexpress
Transcriptomics3' RNA-seq of fly expressing cabut RNAi after exposure to different levels of sucrose
Control (+/cbtE1-UAS-cbt RNAi) or cabut RNAi flies (Tim-gal4, UAS-cbt RNAi) were starved for 16 hours and then exposed to food containing different concentrations of sucrose: 0, 25, 50 and 100 % for 18 hours. Fly heads were collected, RNA was extracted and RNA-seq libraries were prepared as prev...
ORGANISM(S): Drosophila melanogaster 
2015-05-08 | E-GEOD-58854 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse splenic and small intestine lamina propria macrophages
The intestinal immune system must elicit robust immunity against harmful pathogens but restrain immune responses directed against commensal microbes and dietary antigens. The mechanisms that maintain this dichotomy are poorly understood. Here we describe a population of CD11b+F4/80+CD11câ?? macroph...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8868 | biostudies-arrayexpress
UnknownNRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion.
Not available
S-EPMC11230227 | biostudies-literature
UnknownRegulatory T cells inhibit CD8<sup>+</sup> T<sub>RM</sub>-like cells during the early stages of tumor immune escape.
Not available
S-EPMC12633329 | biostudies-literature
TranscriptomicsChIP-chip by array of zebra fish hepatocellular carcinoma and normal liver to detect differences in CG island methylation
The aim of the experiment was to detect differences in CG island methylation between hepatocellular carcinoma and normal liver in zebrafish. Zebrafish were treated with DMBA, producing hepatocellular carcinoma, genomic DNA was prepared from these and control zebrafish livers. Methylated DNA was immu...
ORGANISM(S): Danio rerio 
2011-01-01 | E-MTAB-209 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of dab hepatocellular adenoma liver tumours (Limanda limanda)
A custome-made 8x15k oligonucleotide limanda limanda microarray (Agilent) comprised of 14919 experimental probes, was used to characterize gene expression profiles of dab hepatocellular adenoma tumours from sites of different pollution status in Irish Sea.
ORGANISM(S): Limanda limanda 
2011-11-04 | E-MTAB-734 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Platichthys flesus (flounder) from the North Sea and the Baltic sea and their reactions on being exposed to water of different salinities
The experiment compared flounder from the North Sea and the Baltic sea and their reactions on being exposed to water of different salinities
ORGANISM(S): Platichthys flesus 
2006-12-20 | E-MAXD-22 | biostudies-arrayexpress
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