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Viruses manipulate host cells to enhance their replication, and the identification of host factors targeted by viruses has led to key insights in both viral pathogenesis and cellular physiology. We previously described global changes in cellular protein levels during human immunodeficiency virus (HI...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012263 | Pride
Co-immunoprecipitation of proteins coupled to mass spectrometry has transformed modern biology’s understanding of protein interaction networks. These approaches exploit the selective isolation of tagged proteins by affinity enrichment / purification to identify protein binding partners at scale and ...
ORGANISM(S): Homo sapiens (Human) Rabies virus Nishigahara RCEH 
2025-10-15 | PXD026637 | Pride
The seminal description of cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. As well as APOBEC3G and its homologues, however, we have recently discovered that Vif is also able to degrade the PPP2R5 family of re...
ORGANISM(S): Homo sapiens (Human) 
2020-04-17 | PXD018271 | Pride
primary mammary cells of the tammar were cultured with 5ug/mL E. coli derived lipoteichoic acid or lipopolysaccharide for four hours. Two control groups where tammar primary mammary cells were cultured for zero and four hours without this stimulant were also used.
ORGANISM(S): Macropus eugenii 
Co-immunoprecipitation of proteins coupled to mass spectrometry is critical for the understanding of protein interaction networks. In instances where a suitable antibody is not available, it is common to graft synthetic tags onto target protein sequences and allowing the use of commercially availabl...
ORGANISM(S): Homo sapiens (Human) 
2023-02-21 | PXD028965 | Pride
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
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