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TranscriptomicsChIP-sequencing analysis of Myc binding sites 4 hours after Myc activation in liver and heart tissue, from wild type and R26CAG-c-MycERT2 mice
Aim: To determine Myc binding sites in mouse heart and liver, 4 hours post MycER activation. c-Myc ChIP sequencing performed on chromatin isolated from hearts and livers harvested from wild-type (R26+/+) and R26CAG-c-MycERT2/+ mice 4 hours post administration of (Z)-4-hydroxytamoxifen.
ORGANISM(S): Mus musculus 
2020-02-24 | E-MTAB-7592 | biostudies-arrayexpress
MetabolomicsUntargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat
Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed ...
2023-01-26 | MTBLS748 | MetaboLights
GenomicsChIP-sequencing analysis of RNA Pol II binding sites 4 hours after Myc activation in liver and heart tissue, from wild type and R26CAG-c-MycERT2 mice
Aim: To determine RNA Pol II binding sites in mouse heart and liver, 4 hours post MycER activation. Pol II ChIP sequencing performed on chromatin isolated from hearts and livers harvested from wild-type (R26+/+) and R26CAG-c-MycERT2/+ mice 4 hours post administration of (Z)-4-hydroxytamoxifen.
ORGANISM(S): Mus musculus 
2020-03-06 | E-MTAB-7593 | biostudies-arrayexpress
TranscriptomicsRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Aim: To determine RNA expression levels in the heart of mice 4 hours post Myc activation. Hearts were isolated from 15 day old wild-type (R26+/+) and R26CAG-c-MycERT2/+ mice following 4 hours of MycER activation via administration of (Z)-4-hydroxytamoxifen. Hearts were isolated from adult TetO-HRas;...
ORGANISM(S): Mus musculus 
2020-02-24 | E-MTAB-7595 | biostudies-arrayexpress
UnknownCarboplatin-associated ototoxicity in children with retinoblastoma.
Not available
S-EPMC3341147 | biostudies-literature
GenomicsGEnetics of Nephropathy - an International Effort (GENIE) GWAS of Diabetic Nephropathy in the UK GoKinD and All-Ireland Cohorts

Diabetic kidney disease, or diabetic nephropathy (DN), is one of the leading causes of end-stage renal disease in the United States and worldwide. DN is a common complication of long-standing type 1 and type 2 diabetes. The clinical course is characterized by development of proteinuria a...

phs000389.v1.p1 | EGA
TranscriptomicsRNA-seq of heart from adult mice 4 and 48 hours post MycER activation compared controls
Aim: To determine RNA expression levels in heart tissues of mice 4 and 48 hours post Myc activation. Mice were systemically infected with a cardiomyocyte specific adeno associated virus (AAV9) at 4 to 6 weeks of age. Hearts were isolated from adult mice that had been infected with AAV9-Ccnt1 and we...
ORGANISM(S): Mus musculus 
2020-02-24 | E-MTAB-8462 | biostudies-arrayexpress
TranscriptomicsRNA-seq of purified cardiomocytes from adult mice (+/- AAV-CCNT1) 4 hours post MycER activation compared controls.
Aim: To determine RNA expression levels in heart tissues of mice 4 post Myc activation. Mice were either untreated or systemically infected with a cardiomyocyte specific adeno associated virus (AAV9) at 4 to 6 weeks of age. Cardiomyocytes were isolated from adult mice that were either untreated o...
ORGANISM(S): Mus musculus 
2020-02-24 | E-MTAB-8515 | biostudies-arrayexpress
TranscriptomicsRNA-seq of tissue from adult mice 4 hours post MycER activation compared to wild type controls.
Aim: To determine RNA expression levels in various tissues of mice 4 hours post Myc activation. Tissues were isolated from adult wild-type (R26+/+) and R26CAG-c-MycERT2/+ mice following 4 hours of MycER activation via administration of (Z)-4-hydroxytamoxifen.
ORGANISM(S): Mus musculus 
2020-02-24 | E-MTAB-7636 | biostudies-arrayexpress
MetabolomicsContribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice
The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fun...
2022-01-14 | MTBLS1679 | MetaboLights
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