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TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in glomeruli from human kidneys with diabetic nephropathy
Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Keywords = Diabetes Keywords = kidney Keywords = glomeruli Keywords: other. This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2004-04-01 | E-GEOD-1009 | biostudies-arrayexpress
TranscriptomicsPulsatile exposure to simulated reflux leads to stereotypical changes in gene expression in a 3D model of oesophageal mucosa
Oesophageal exposure to duodenogastroesophageal refluxate is implicated in the development of BarrettM-bM-^@M-^Ys Metaplasia, with increased risk of progression to oesophageal adenocarcinoma. The literature proposes that reflux exposure activates NF-kB, driving the aberrant expression of intestine-s...
ORGANISM(S): Homo sapiens 
2013-03-22 | E-GEOD-45380 | biostudies-arrayexpress
TranscriptomicsAnalysis of postnatal gene expression in a transgenic rat kidney
We have generated a transgenic rat model with postnatal pathology. In order to investigate the potential contribution of changes in kidney gene expression to the pathology, we have conducted microarray-based gene expression profiling of postnatal kidney. Rat kidneys were sampled at mid-day of post...
ORGANISM(S): Rattus norvegicus 
2012-10-02 | E-GEOD-38595 | biostudies-arrayexpress
TranscriptomicsRole of NFBD1 in global gene expression
NFBD1 (nuclear factor with BRCT domains 1), also known as MDC1 (mediator of DNA damage signaling 1), is a protein involved in the ATM signaling pathway in response to DNA damage. In addition to a role in signaling, NFBD1 possesses transactivation activity, suggesting that it may influence transcrip...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-23010 | biostudies-arrayexpress
MetabolomicsUntargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models
The application of ketogenic diet (KD) (high fat/low carbohydrate/adequate protein) as an auxiliary cancer therapy is a field of growing attention. KD provides sufficient energy supply for healthy cells, while possibly impairing energy production in highly glycolytic tumor cells. Moreover, KD regula...
2019-10-08 | MTBLS1066 | MetaboLights
ProteomicsMitochondrial microproteins link metabolic cues to respiratory chain biogenesis
Electron transport chain (ETC) biogenesis is tightly coupled to energy levels and availability of ETC subunits. Coenzyme Q: cytochrome c oxidoreductase (complex III or CIII) occupies a central position in the ETC, receiving electrons from diverse fuel sources to control the ubiquinol:ubiquinone (CoQ...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-25 | PXD030258 | Pride
Metabolism Sep Mitochondria Oxphos Micropeptides 
TranscriptomicsTranscription profiling of individual bovine nuclear transfer blastocysts
Individual zona free in vitro grown bovine day 7 blastocysts were compared to stage and quality matched nuclear transfer derived blastocysts (fibroblast donor cells).
ORGANISM(S): Bos taurus 
2006-02-14 | E-MEXP-556 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mesangial cell line MES-13 to examine the global effects of high glucose (HG) and glucosamine (GlcN) on the transcriptome.
The renal mesangial cells play an important role in the development of diabetic glomerulosclerosis and renal failure. We have previously demonstrated some of the effects of high glucose are mediated via the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosami...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2557 | biostudies-arrayexpress
TranscriptomicsComparative RNAseq analysis of CSF1-stimulated chicken bone marrow-derived macrophages and embryonic RNA
RNAs were analysed from a pool of day 7 chicken embryos, the DF-1 chicken fibroblast cell line and chicken bone marrow-derived macrophages (stimulated with CSF-1).
ORGANISM(S): Gallus gallus 
2015-01-19 | E-MTAB-3048 | biostudies-arrayexpress
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