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MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
UnknownA novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury.
Not available
S-EPMC4195246 | biostudies-literature
MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
UnknownJoint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.
Not available
S-EPMC3852929 | biostudies-literature
GenomicsSMG
Severe malaria cases from Gambia
EGAD00000000018 | EGA
UnknownGenetic architecture of circulating lipid levels.
Not available
S-EPMC3137496 | biostudies-literature
UnknownAssociation of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort.
Not available
S-EPMC7818323 | biostudies-literature
TranscriptomicsChIP-chip from human fetal brain with H3K27Ac and H3K4Me1
Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage. We tested this concept experimentally using the human X chromosome. We describe a scoring m...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-57354 | biostudies-arrayexpress
TranscriptomicsChIP-chip from mouse 14.5 days fetal brain with P300 and H3K4Me1
Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage. We tested this concept experimentally using the human X chromosome. We describe a scoring m...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-57357 | biostudies-arrayexpress
UnknownDNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features.
Not available
S-EPMC12209777 | biostudies-literature
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