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ProteomicsWDR5 protein interactions at the WIN-site
The WIN site of WDR5 is a druggable pocket that impairs WDR5 protein function and carries therapeutic potential for treating cancer. This study evaluates the protein interactions affected by small molecule blockade of this surface on WDR5. Inhibited and uninhibited WDR5-containing complexes from HEK...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD019209 | Pride
Silac Wdr5 Immunoprecipitation Signaling Chromatin 
ProteomicsPeptidoglycan recycling is critical for cell division, cell wall integrity and β-lactam resistance in Caulobacter crescentus
Most bacteria possess a peptidoglycan cell wall, which is continuously remodeled during cell growth and divi¬sion. The peptidoglycan (PG) fragments generated in this process are typically imported into the cell and recycles through the PG biosynthesis pathway. While the underlying pathways have been...
ORGANISM(S): Caulobacter crescentus (strain NA1000 / CB15N) 
2026-03-11 | PXD069004 | Pride
Peptidoglycan Cell wall recycling Β-lactamase 
TranscriptomicsAdult mouse stage synchronized testis array
WIN 18,446/RA treatment of neonatal male mice was used to synchronize spermatogenesis to 2-3 different stages of the cycle of the seminiferous epithelium in the adult testis 6 different groups of synchronized adult mouse testis samples (N = 2 per group), each representing only 2-3 stages of the cycl...
ORGANISM(S): Mus musculus 
2014-12-17 | E-GEOD-64214 | biostudies-arrayexpress
ProteomicsBiochemical specialization of an ATG8 isoform in Nicotiana benthamiana
ATG8 is a highly-conserved ubiquitin-like protein that modulates autophagy pathways by binding autophagic membranes and numerous proteins, including cargo receptors and core autophagy components. Throughout plant evolution, ATG8 has expanded from a single protein in algae to multiple isoforms in hig...
ORGANISM(S): Nicotiana benthamiana 
2019-11-12 | PXD011484 | Pride
Atg8 Phytophthora infestans Pexrd54 Autophagy Nicotiana benthamiana 
TranscriptomicsDifferent isoforms of Maxwell´s Demon, a conserved cell membrane protein, mediate lose/win decisions during cell competition
Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish “winners” from “losers” during cell competition. Using genomic and functional assays we have identified Maxwell`s Demon (Mwd), a cell membr...
ORGANISM(S): Drosophila melanogaster 
2011-02-09 | E-GEOD-21230 | biostudies-arrayexpress
GenomicsFOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index [ChIP-Seq]
FOXM1 is a key transcription factor regulating cell cycle progression, DNA damage response, and a host of other hallmark cancer features, but the role of the FOXM1 cistrome in driving estrogen receptor-positive (ER+) vs. ER- breast cancer clinical outcomes remains undefined. Chromatin immunoprecipit...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-72977 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cells expressing FoxM1-ER fusion protein
Experiment description To identify FoxM1-regulated genes, we carried out gene expression profile analysis after inducible activation of a FoxM1-ER fusion protein using high-density human cDNA microarrays. We constructed a stable line of U2OS cells expressing full-length HA-FoxM1 fused at its C-term...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-MEXP-230 | biostudies-arrayexpress
TranscriptomicsFOXM1 Orchestrates a Global Methylation Signature that Mimics the Cancer Epigenome
Aberrant upregulation of a single oncogene FOXM1 in primary normal human oral epithelial cells orchestrated a cancer-like methylome landscape This study have identified a unique FOXM1-induced epigenetic signature which may have potentials as biomarkers for early oral cancer screening, diagnostic and...
ORGANISM(S): Homo sapiens 
2012-04-18 | E-GEOD-31767 | biostudies-arrayexpress
GenomicsIdentification of cell cycle-regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors [ChIP-seq]
We report the genome wide DNA binding patterns of wild type FOXM1 in asynchronous HeLa cells using chromatin precipitation followed by high-throughput sequencing (ChIP-seq). We find that FOXM1 is bound to the promoter of a number of cell cycle genes including PLK, AURKB, and CCNB1. FOXM1 ChIP-seq i...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-52098 | biostudies-arrayexpress
UnknownA robust bacterial assay for high-throughput screening of human 4-hydroxyphenylpyruvate dioxygenase inhibitors.
Not available
S-EPMC6775094 | biostudies-literature
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