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ProteomicsIFITM3 BioID Interactomes in B-ALL and MCL
To determine the roles of membrane associated IFITM3 in BCR-signalling in B-cell malignancies we expressed N-terminal BirA-IFITM3-Y20E fusion or BirA-EV control in patient derived B-ALL cells (PDX2) and Jeko1 Mantle cell lymphoma (MCL) cells. Additionally to examine the role of PIP3 binding residues...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020697 | Pride
Human b-all mcl b-cells 
UnknownDendritic Cell Vaccination in Conjunction with a TLR Agonist Polarizes Interferon Immune Responses in Malignant Glioma Patients.
Not available
S-EPMC10543402 | biostudies-literature
TranscriptomicsTranscription profiling of intraepithelial and peripheral CTL from patients with celiac disease or cytomegalovirus seropositive patients suggest that a stepwise transformation of CTLs into NK-like cells may underlie immunopathology in various chronic infectious and inflammatory diseases.
Celiac disease is an intestinal inflammatory disorder induced by dietary gluten in genetically susceptible individuals. The mechanisms underlying the massive expansion of interferon g–producing intraepithelial cytotoxic T lymphocytes (CTLs) and the destruction of the epithelial cells lining the sm...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4592 | biostudies-arrayexpress
UnknownReprogramming of CTLs into natural killer-like cells in celiac disease.
Not available
S-EPMC2121214 | biostudies-literature
UnknownPlanning and optimising CHAT&PLAN: A conversation-based intervention to promote person-centred care for older people living with multimorbidity.
Not available
S-EPMC7567392 | biostudies-literature
UnknownTLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial.
Not available
S-EPMC11078958 | biostudies-literature
ProteomicsIFITM3-mediated regulation of cell membrane dynamics is essential for malignant B-cell transformation
B cell receptor (BCR) signaling and oncogenic tyrosine kinases that mimic BCR-signaling in B-lineage leukemia and lymphoma depend on assembly of membrane proximal signaling complexes. Signalosomes in normal BCR- and oncogene (e.g. BCR-ABL1, RAS-pathway lesions) signal transduction are recruited to p...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-18 | PXD014691 | Pride
Leukemia Bcr signaling Cell surface Lipid rafts 
ProteomicsIFITM3 amino acid mutants phosphoproteomics
To investigate the role of IFITM3 in B-ALL, patient derived xenograft cells PDX2 were transduced with either a the constitutively membrane associated IFITM3-Y20E mutant or EV control. Additional mutation of PIP3 binding sites within the conserved internal loop region - K83/K104 or R85/R87/K88 - were...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020696 | Pride
Pdx b-all b-cell 
UnknownTelerehabilitation in Physical Therapist Practice: A Clinical Practice Guideline From the American Physical Therapy Association.
Not available
S-EPMC11140266 | biostudies-literature
UnknownAntibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.
Not available
S-EPMC7618792 | biostudies-literature
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