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MetabolomicsExtracts from sweet sorghum (Sorghum bicolor), a feedstock for biorefining, suppressed proliferation and elevated apoptosis in human colon cancer stem cells via suppression of Wnt/beta-catenin signaling pathway
In colorectal cancer, p53 is commonly inactivated, associated with chemo-resistance, and marks the transition from non-invasive to invasive disease. Cancers, including colorectal cancer, are thought to be diseases of aberrant stem cell populations, as stem cells are able to self-renew, making them l...
2014-05-01 | MTBLS69 | MetaboLights
TranscriptomicsTranscription profiling of mouse pancreas at embryonic days 14.5 and 16.5 from animals lacking beta-catenin, a mediator of Wnt signaling and a component of the cadherin-catenin epithelial adhesion complex
Beta-catenin is an essential mediator of canonical Wnt signaling and a central component of the cadherin-catenin epithelial adhesion complex. Dysregulation of beta-catenin expression has been described in pancreatic neoplasia. Newly published studies have suggested that beta-catenin is critical for ...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7430 | biostudies-arrayexpress
TranscriptomicsIdentification of beta-catenin-associated RNAs in myeloid leukaemia cells through RIP-seq
Myeloid cell lines (K562 and HEL) were treated overnight with CHIR99021 or a vehicle control (DMSO). CHIR99021 treatment inhibits GSK3B within the destruction complex functioning in Wnt/beta-catenin signalling pathway, thereby preventing beta-catenin degradation and promoting its stabilization. Foll...
ORGANISM(S): Homo sapiens 
2025-04-08 | E-MTAB-14675 | biostudies-arrayexpress
TranscriptomicsUse of an activated beta-catenin to identify Wnt/beta-catenin pathway target genes in C. elegans, including a subset of collagen genes expressed in late larval development
The Wnt signaling pathway plays a fundamental role during the development of metazoans, where it functions in the regulation of diverse processes including cell fate specification, cell migration, and stem cell renewal. Activation of the beta-catenin dependent or canonical Wnt signaling pathway upr...
ORGANISM(S): Caenorhabditis elegans 
2014-05-13 | E-GEOD-51502 | biostudies-arrayexpress
ProteomicsE3 ubiquitin-ligase Hakai induces LRP4 degradation and regulates Wnt/β-catenin signalling in colorectal cancer cells
The epithelial-mesenchymal transition (EMT) is closely linked to the acquisition of cancer stem cell (CSC) properties, which contribute to treatment resistance and metastasis. This study investigates the role of the E3 ubiquitin-ligase Hakai, the first identified post-translational regulator of E-ca...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD069248 | Pride
E3 ubiquitin-ligase hakai  lrp4  wnt/β-catenin pathway  cancer stem cell  colon cancer. 
TranscriptomicsTranscription profiling of mouse intestinal crypts upon deletion of beta-catenin
The Wnt signaling pathway is deregulated in over 90% of human colorectal cancers. β Catenin, the central signal transducer of the Wnt pathway, can directly modulate gene expression by interacting with transcription factors of the TCF/LEF-family. In the present study we investigate the role of Wnt s...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8818 | biostudies-arrayexpress
TranscriptomicsEctopic activation of Wnt/beta-catenin signaling in lens fiber cells results in cataract formation.
Transgenic mouse line called alphaA-CLEF in which transactivation domain of beta-catenin is fused to the amino terminus of DNA-binding protein LEF and the expression of transgenic protein is controlled by alphaA-crystallin promoter (-342/+49) was used to mimic the activation of canonical Wnt/beta-c...
ORGANISM(S): Mus musculus 
2014-02-11 | E-MTAB-1691 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse kideney FROM beta catenin deficient animals vs controls AT E12.5
We generated a murine genetic model of beta-catenin deficiency targeted to the ureteric bud cell lineage to study the role of beta-catenin mediated Wnt signaling during ureteric morphogenesis. Experiment Overall Design: A comparison was made between triplicate samples of E12.5 kidneys from either no...
ORGANISM(S): Mus musculus 
2008-04-04 | E-GEOD-9629 | biostudies-arrayexpress
ProteomicsThe Ewing sarcoma secretome and its response to activation of Wnt/beta- catenin signaling
Tumor: tumor microenvironment (TME) interactions are critical for tumor progression and the composition and structure of the local extracellular matrix (ECM) are key determinants of tumor metastasis. We recently reported that activation of Wnt/beta- catenin signaling in Ewing sarcoma cells induces w...
ORGANISM(S): Homo sapiens (Human) 
2018-02-07 | PXD007909 | Pride
Ewing sarcoma Wnt/beta-catenin Label-free mass spectrometry Extracellular matrix Secretome Tumor microenvironment 
ProteomicsFOX transcription factors are common regulators of Wnt/β-catenin signaling
The Wnt/β-catenin signaling pathway is a critical regulator of development and stem cell maintenance. Mounting evidence suggests that the context-specific outcome of Wnt signaling is determined by the collaborative action of multiple transcription factors, including members of the highly conserved f...
ORGANISM(S): Homo sapiens (Human) 
2023-04-19 | PXD038811 | Pride
Fox transcription factors Turboid Wnt signaling Lc-ms/ms 
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