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ProteomicsMulti-Omic analyses reveal aberrant differentiation trajectory with WNT1 Loss-of-Function in type XV osteogenesis imperfecta
Osteogenesis imperfecta (OI) is a serious genetic bone disorder characterized by congenital low bone mass, deformity and frequent fractures. Type XV OI is a moderate to severe form of skeletal dysplasia caused by WNT1 mutations. In this cohort study from southern China, we summarized the clinical ph...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD050841 | Pride
Human Bone Osteogenesis imperfecta 
GenomicsExpression Data from ST2 cells treated with Wnt1
Expression Data from ST2 cells treated with Wnt1
PRJNA870090 | ENA
TranscriptomicsRNA-seq of murine macrophages (J774A.1 and Raw264.7) grown for 48 hours in conditioned media collected from primary murine Triple Negative Breast Cancer cells
The goal of the experiment was to demonstrate if the overexpression of human-Prune-1 in Triple Negative breast cancer cells induces M2-polarization of macrophages in vitro. For this purpose, murine primary cells from breast tumor developed by Genetically Engineered Mouse Models (GEMMs) of TNBC (i.e....
ORGANISM(S): Mus musculus 
2020-12-03 | E-MTAB-9231 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Wnt-1 overexpressing melanoma
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and n...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-26656 | biostudies-arrayexpress
Genomicsbulk RNA-seq of wild-type, Gli2f/f Gli3f/f Wnt1-Cre, and Hand2f/f Wnt1-Cre mouse e10.5 dissection mandibular prominences
bulk RNA-seq of wild-type, Gli2f/f Gli3f/f Wnt1-Cre, and Hand2f/f Wnt1-Cre mouse e10.5 dissection mandibular prominences
PRJNA593447 | ENA
GenomicsExpression Data from ST2 cells treated with recombinant Wnt1
Expression Data from ST2 cells treated with recombinant Wnt1
PRJNA1370863 | ENA
TranscriptomicsmiRNA expression profiling of stage specific monocyte derived dendritic cell differentiation
MicroRNAs (miRNAs, miRs) modulate a multitude of cellular events. Here, we identify functional miRNA-protein networks that regulate human monocyte-derived dendritic cell (MDDC) differentiation. MiRNA profiling revealed stage-specific differential expression of 20 miRNAs during days 1, 3 and 5 of MD...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-15644 | biostudies-arrayexpress
GenomicsExpression Data from ST2 cells transfected with a Wnt1 expressing plasmid
Expression Data from ST2 cells transfected with a Wnt1 expressing plasmid
PRJNA1048465 | ENA
TranscriptomicsSuppressed cytokine and chemokine transcriptional signatures in mammary stem/progenitor cells are associated with dietary protection against Wnt1-driven mammary tumorigenesis
Maintenance and propagation of breast cancer stem cells (BCSCs) is mediated via cytokine and growth factor networks. Direct in vivo linkage between dietary regulation of mammary stem (MaSC)/progenitor cell numbers and protection from breast cancer has not been reported. Here, we investigated the eff...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-37849 | biostudies-arrayexpress
Transcriptomicswnt1-induced mammary tumor from Rarb KO mice vs. those from Rarb wt (control)
Previously we have demonstrated that inactivation of retinoic acid receptor beta (Rarb) in the mouse results in a protective effect against ErbB2-induced mammary gland tumorigenesis although Rarb has been reported as a tumor suppressor before. In the current study, we further confirmed that ablation...
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-56391 | biostudies-arrayexpress
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