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This dataset presents a high-resolution, label-free quantitative (LFQ) bottom-up proteomic analysis profiling the molecular rearrangements within the cerebellar tissue architecture following the knockdown of the wingless-type MMTV integration site family, member 10B (Wnt10b) ligand. Using organotypi...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-02 | PXD079944 | Pride
Loss of YY1 in Purkinje Cells Triggers Cerebellar Ataxia via Wnt10b-Mediated Impairment of Dendrite Development
The cerebellum relies on Purkinje cells (PCs) to coordinate motor functions and maintain neural circuitry. Impaired PC dendritogenesis is linked to neurological disorders, yet intrinsic molecular mechanisms remain unclear. We demonstrate that postnatal deletion of Yin Yang 1 (Yy1) in PCs disrupts de...
ORGANISM(S): Mus musculus 
2026-06-23 | GSE336211 | GEO
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