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ProteomicsAre you also what Your Mother Eats? Distinct Proteomic Portrait as a Result of Maternal High-Fat Diet in the Cerebral Cortex of the Adult Mouse.
Background: Epidemiological studies suggest an association between maternal obesity and adverse neurodevelopmental outcomes in offspring. Objective: To compare the global proteomic portrait in the cerebral cortex between mice born to mothers on a high-fat or control diet who themselves were fed a h...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-29 | PXD001540 | Pride
2d lc-ms/ms Proteomics Brain Obesity High-fat diet Cerebral cortex Itraq Maternal 
TranscriptomicsRole of CCR2+ myeloid cells in pancreatic β cell growth and regeneration
Pancreas and spleen were microdissected from wild type (C57B6/SV129 background) E14.5 embryos and P0 newborn pups. Pools of 30-60 tissues were used. Tissues were digested for 1 hour at 37°C in HBSS/0.1% collagenase A/20 µg/ml DNase I, followed by dissociation of the cell clusters into single cells...
ORGANISM(S): Mus musculus 
2017-12-06 | E-MTAB-5427 | biostudies-arrayexpress
TranscriptomicsA gp130-induced Src/Yes-YAP Cascade Links Inflammation to Regeneration in the Mammalian Intestine
gp130Act cDNA was PCR-amplified and inserted into a plasmid containing the 12.4-kb Villin promoter. The 15.7-kb expression cassette was excised by PmeI digestion, purified, and injected into fertilized C57BL/6 oocytes to obtain founder mice, two of which transmitted the gp130Act transgene. Small int...
ORGANISM(S): Mus musculus 
2015-02-21 | E-MTAB-2400 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression in HIV-Infected Individuals Following ART.
A paired analysis of peripheral blood mononuclear cells (PBMCs) isolated before and after antiretroviral therapy (ART) from a robust number of HIV-infected patients (N=36). Results identify a total of 4,157 DEGs following ART in HIV-infected participants and the transition from a period of active vi...
ORGANISM(S): Homo sapiens 
2013-09-10 | E-GEOD-44228 | biostudies-arrayexpress
UnknownAre you also what your mother eats? Distinct proteomic portrait as a result of maternal high-fat diet in the cerebral cortex of the adult mouse.
Not available
S-EPMC5399160 | biostudies-literature
TranscriptomicsGene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours.
Purpose: Human papilloma virus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than HPV(-) negative cancer. This may be due, in part, to the higher number of tumour infiltrating lymphocytes (TIL) in HPV(+) tumours. We used RNAseq to evaluate whether these differ...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72536 | biostudies-arrayexpress
TranscriptomicsInfluence of NSD3 and ESR1 knockdown on gene expression in SUM-44 cells
Total RNA was isolated from SUM-44 cells subjected to 5 days of puromycin selection following infection with lentiviral shRNA constructs against NSD3-S or ESR1 as well as LacZ control. Samples were harvested in triplicate and prepared and sequenced simultaneously.
ORGANISM(S): Homo sapiens 
2018-09-01 | E-MTAB-5823 | biostudies-arrayexpress
UnknownSuberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells.
Not available
S-EPMC3752851 | biostudies-literature
UnknownStructural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis.
Not available
S-EPMC4671310 | biostudies-literature
ProteomicsFat BodFat Body, Hungry Brain: Nutriproteomics in the Hypothalamus from a Mouse Model with Obesity and Anorexiay, Hungry Brain: Nutriproteomics in the Hypothalamus from a Mouse Model with Obesity and Anorexia
Systemic acute inflammatory signals can cause profound anorexia by disrupting the physiological appetite regulation in the hypothalamic milieu. Conversely, obesity related chronic inflammation of the hypothalamus can disturb anorexigenic signals and promote abnormal body weight control. The aim of t...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-29 | PXD002119 | Pride
Hypothalamus Proteomics Obesity Anorexia Acute inflammation Chronic inflammation 
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