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TranscriptomicsGene expression in human fungal pathogen Coccidioides immitis changes as mycelia differentiate into spherules and mature
Coccidioides immitis (C. immitis) is a dimorphic fungus that causes disease in mammals including human beings. It grows as a mycelium in the soil but differentiates into a pathogenic structure called a spherule in the host. We compared the transcriptome of C. immitis mycelia and day 2 and day 8 sphe...
ORGANISM(S): Coccidioides immitis RS 
2013-07-11 | E-GEOD-44225 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression in HIV-Infected Individuals Following ART.
A paired analysis of peripheral blood mononuclear cells (PBMCs) isolated before and after antiretroviral therapy (ART) from a robust number of HIV-infected patients (N=36). Results identify a total of 4,157 DEGs following ART in HIV-infected participants and the transition from a period of active vi...
ORGANISM(S): Homo sapiens 
2013-09-10 | E-GEOD-44228 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours.
Purpose: Human papilloma virus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than HPV(-) negative cancer. This may be due, in part, to the higher number of tumour infiltrating lymphocytes (TIL) in HPV(+) tumours. We used RNAseq to evaluate whether these differ...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72536 | biostudies-arrayexpress
TranscriptomicsExpression profile of colon crypts from WT and GMCSF-/- mice with or without DSS treatment
To discover possible molecular mechanisms mediated by GM-CSF that may be involved in regeneration of the colon epithelium after DSS-induced injury we performed whole-genome wide mRNA microchip analysis of isolated crypt epithelial cells from unchallenged and DSS-challenged WT and GM-CSF-/- mice. Tot...
ORGANISM(S): Mus musculus 
2012-11-21 | E-GEOD-42173 | biostudies-arrayexpress
TranscriptomicsFactors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection.
Mouse strains have been identified that are resistant (i.e. DBA/2) or susceptible (i.e. C57BL/6) to infection from pathogenic fungus Coccidioides immitis. However, the genetic and immunological basis for this difference has not been fully characterized. Microarray technology was used to identify ge...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-40379 | biostudies-arrayexpress
TranscriptomicsSuberoylanilide hydroxamic acid (SAHA) induces limited changes in the transcriptome of primary CD4+ T cells
This study evaluated primary CD4+ T cell gene expression treated with pharmacologically achievable concentration (340 nM) of SAHA for 24 hours in order to evaluate potential side effects of this compound in cells relevant to HIV infection. Analysis of human primary CD4+ T cells taken from 9 healthy ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-41504 | biostudies-arrayexpress
TranscriptomicsHIV downregulates interferon stimulated genes in primary macrophages.
HIV is able to outpace the innate immune response, including the response mediated by interferon (IFN), to establish a productive infection. However, monocyte derived macrophages (MDMs) may be protected from HIV infection by treatment with type I IFN before virus exposure. The ability of HIV to mo...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-41731 | biostudies-arrayexpress
TranscriptomicsThe effect of cell subset isolation method on gene expression in leukocytes.
Analysis of the effect of isolation methods (fluorescence activated cell sorting (FACS), positive and negative immunomagnetic selection) on gene expression in human primary CD4+, CD8+ T cells, B cells and monocytes. FACS incurs the least short-term changes in gene expression signature. This study ev...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-GEOD-50008 | biostudies-arrayexpress
TranscriptomicsCD4+ T cell gene expression in virologically suppressed HIV-infected patients during Maraviroc intensification therapy.
Analysis of CD4+ T cell gene expression changes after 4 and 24 weeks of Maraviroc administration relative to baseline in 25 immunodiscordant patients with viral suppression. Maraviroc elicited very modest changes in CD4+ T cell transcriptome. The goal of this study was to identify genes with a poten...
ORGANISM(S): Homo sapiens 
2014-04-16 | E-GEOD-56804 | biostudies-arrayexpress
TranscriptomicsExpression data from IFN alpha 2-treated macrophages infected with HIV
Temporal changes of the expression levels of the complete human transcriptome during the first 24 hours following infection of IFN-pre-treated macrophages. This approach has allowed us to identify genes involved in the IFN signaling that have an impact on HIV-1 infection of macrophages KEYWORDS: tim...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-30536 | biostudies-arrayexpress
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