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ProteomicsIn-depth proteomic analyses reveal unique subtype-specific signatures in small cell lung cancer (part II: cell media)
Small-cell lung cancer (SCLC) represents about 13–15% of all lung cancers and with a five-year survival rate of less than 7%, it remains one of the most lethal forms of malignant diseases. It has a very aggressive course and is characterized by extensive chromosomal rearrangements, high mutation bur...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD029821 | Pride
Sclc Proteomics Cell lines Molecular subtypes 
ProteomicsIn-depth proteomic analyses reveal unique subtype-specific signatures in small cell lung cancer (part I: cell pellets)
Small-cell lung cancer (SCLC) represents about 13–15% of all lung cancers and with a five-year survival rate of less than 7%, it remains one of the most lethal forms of malignant diseases. It has a very aggressive course and is characterized by extensive chromosomal rearrangements, high mutation bur...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD029805 | Pride
Sclc Proteomics Cell lines Molecular subtypes 
UnknownToxicoproteomics Disclose Pesticides as Downregulators of TNF-α, IL-1β and Estrogen Receptor Pathways in Breast Cancer Women Chronically Exposed.
Not available
S-EPMC7483484 | biostudies-literature
ProteomicsProteomic characterization of primary and brain metastatic lung adenocarcinomas in a well-defined patient cohort
Lung adenocarcinoma (LADC) is the most common subtype of non-small cell lung cancer (NSCLC). One major feature of disease progression is the metastatic spread to the central nervous system (CNS). Treatment regimens for brain metastases are limited, thus distant metastases remain the leading cause of...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027259 | Pride
Cancer progression Ffpe samples Lung adenocarcinoma Clinical proteomics Brain metastasis 
ProteomicsToxicoproteomic-based screening discloses pivotal downregulated mechanisms triggered by chronic pesticide exposure in breast cancer patients.
Pesticides are chemical compounds widely used in agriculture to control pests, since the 1960s. Regardless of its specific targets, such substances, unfortunately, can reach the human organism, and negative cumulative effects have been reported in people worldwide. Chronic exposure to pesticides has...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018577 | Pride
Breast cancer Toxicoproteomic Pesticide exposure Lcms 
ProteomicsProteomic workflows for high quality quantitative proteome and PTM analysis of clinically relevant samples from FFPE archives
Well-characterized archival FFPE tissues are of much value for prospective biomarker discovery studies. Protocols that offer high-throughput and good reproducibility are essential in proteomics. Therefore, we developed a workflow implementing efficient paraffin removal and protein extraction from FF...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD021986 | Pride
Cancer Lung adenocarcinoma Suspension trapping (s-trap) Lysine acetylation stoichiometry Mass spectrometry Clinical proteomics Ffpe tissue Sample preparation High-throughput Isobaric labeling (tmt) 
UnknownMapping the Melanoma Plasma Proteome (MPP) Using Single-Shot Proteomics Interfaced with the WiMT Database.
Not available
S-EPMC8699267 | biostudies-literature
ProteomicsClinical proteomics workflow for high quality quantitative proteome and PTM analysis of biologically relevant FFPE tissue samples
In recent years, the use of formalin-fixed paraffin-embedded (FFPE) tissues has increased within cancer research and clinical proteomics. However, the use of FFPE tissues can be demanding due to paraffin embedding and cross-links introduced by the formaldehyde. Here, we developed a workflow implemen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020157 | Pride
Cancer Suspension trapping Lung adenocarcinoma Mass spectrometry Clinical proteomics Lysine acetylation stoichiomtery Throughput Proteomics Tissue Isobaric labeling Tmt Ffpe Sample preparation S-trap 
ProteomicsMapping the Melanoma Plasma Proteome (MPP) using Single-Shot Proteomics and Custom Protein Databases
We mapped the Melanoma Plasma Proteome (MPP) of undepleted samples a new strategy for protein identification refered here as Wise MS transfer (WiMT). We were able to identify more than 1,000 protein in undepleted plasma samples which shows a deep coverage of the plasma proteome. The MPP of undeplted...
ORGANISM(S): Homo sapiens (Human) 
2021-12-27 | PXD028709 | Pride
Malignant melanoma  plasma  proteome  proteomics  biomarkers  wimt 
UnknownProteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases.
Not available
S-EPMC10024110 | biostudies-literature
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