Sort   by:  
 Page size 
UnknownA matrix-assisted laser desorption ionization-time-of-flight-time-of-flight-mass spectrometry-based toxicoproteomic screening method to assess in vitro particle potencies.
Not available
S-EPMC6220844 | biostudies-literature
UnknownIn vitro toxicoproteomic analysis of A549 human lung epithelial cells exposed to urban air particulate matter and its water-soluble and insoluble fractions.
Not available
S-EPMC5625787 | biostudies-literature
ProteomicsToxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid
Tuberculosis is a global health threat that affects millions of people every year, and treatment-limiting toxicity remains a considerable source of treatment failure. Recent reports have characterized the nature of hPXR-mediated hepatotoxicity and systemic toxicity of antitubercular drugs. The antit...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-19 | PXD019505 | Pride
Anemia  antitubercular therapy  cytochrome p450  drug-induced liver injury  heme biosynthesis  hypercoagulability  iron–sulfur cluster  pellagra  vitamin b3  vitamin b6 
ProteomicsToxicoproteomic-based screening discloses pivotal downregulated mechanisms triggered by chronic pesticide exposure in breast cancer patients.
Pesticides are chemical compounds widely used in agriculture to control pests, since the 1960s. Regardless of its specific targets, such substances, unfortunately, can reach the human organism, and negative cumulative effects have been reported in people worldwide. Chronic exposure to pesticides has...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018577 | Pride
Breast cancer Toxicoproteomic Pesticide exposure Lcms 
UnknownToxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS.
Not available
S-EPMC4442484 | biostudies-literature
UnknownToxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid.
Not available
S-EPMC7407182 | biostudies-literature
UnknownToxicoproteomics Disclose Pesticides as Downregulators of TNF-α, IL-1β and Estrogen Receptor Pathways in Breast Cancer Women Chronically Exposed.
Not available
S-EPMC7483484 | biostudies-literature
ProteomicsCytotoxicity and Toxicoproteomic Analysis of Pioglitazone Exposure in Human-derived Cardiomyocytes
Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor gamma agonist widely used as an insulin sensitiser agent for type II diabetes mellitus. The heterogeneity of PGZ effects on cardiac tissue has remained controversial, as contradictory data exist in the literature. Nevertheless, a con...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048231 | Pride
Pioglitazone  mitochondrial dysfunction  wgcna  label-free protein quantification 
ProteomicsToxicoproteomic and lipidomic analysis of human lung cells chronically exposed to MWCNT
Multi-walled carbon nanotubes (MWCNT) present a wide variety of exciting application opportunities. As MWCNT are produced in large quantities, occupational exposure and human health is of particular concern. However, there is no consensus regarding their potential harmful effects. In particular, chr...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD005970 | Pride
Carbon nanotubes Lc-msms Genotoxicity Toxicoproteomics Lipidomics Label free quantification Long-term exposure Apoptosis Human Mwcnt 
ProteomicsToxicoproteomics reveals an effect of Clozapine on autophagy in human liver spheroids
Clozapine is an atypical antipsychotic drug used to treat treatment-resistant schizophrenia. Its side effects, including liver enzyme abnormalities, experienced by many patients preclude its more common use as a first-line therapy for schizophrenia. Toxicoproteomic approaches have been demonstrated ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-13 | PXD038007 | Pride
Drug-induced liver injury  data-independent acquisition  clozapine  proteomics  systems toxicology 
Sort   by:  
 Page size