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TranscriptomicsIntegrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
The saprophytic mold Aspergillus fumigatus produces small (2-3 µm) airborne spores (conidia) that can reach the lung alveoli upon inhalation. There, they encounter the surfactant-rich environment of the alveolar epithelium and initiate swelling and germination. Primary alveolar macrophages are essen...
ORGANISM(S): Homo sapiens 
2026-10-02 | E-MTAB-17130 | biostudies-arrayexpress
UnknownDog Owners' Perceptions of Canine Body Composition and Effect of Standardized Education for Dog Owners on Body Condition Assessment of Their Own Dogs.
Not available
S-EPMC10386090 | biostudies-literature
ProteomicsThe Drosophila acetyltransferase chameau (chm) promotes starvation resilience at the expense of a shortened life span
Proteins involved in cellular metabolism and molecular regulation have been shown to extend lifespan in various laboratory organisms. However, for any improvement in aging to confer an evolutionary benefit, organisms must also be able to survive under non-ideal conditions. Earlier, we discovered tha...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-09-05 | PXD042471 | Pride
Chameau Acetylation Starvation Hbo1 Drosophila 
TranscriptomicsBezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice
Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), is generally used to treat hyperlipidemia. Clinical trials on patients suffering from type 2 diabetes indicated that BEZ also has beneficial effects on glucose metabolism, but the underlying mechanisms remain ...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-79008 | biostudies-arrayexpress
UnknownIncreased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA.
Not available
S-EPMC7524039 | biostudies-literature
TranscriptomicsDefective removal of ribonucleotides from DNA promotes systemic autoimmunity
Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signalin...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-63755 | biostudies-arrayexpress
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