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ProteomicsSex-Specific Microglia Defects in the Neuroligin-4 Knock-Out Mouse Model of Autism Spectrum Disorder
Neuroligin-4 (NL4) loss-of-function mutations are strongly associated with monogenic heritable abnormalities linked with Autism Spectrum Disorder (ASD). NL4 mutation in mice causes ASD related alterations in both, the synaptic and behavioral phenotype. Since microglia closely regulate synaptic devel...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD024325 | Pride
Sex difference Gamma oscillation Estrogen Microglia Autism spectrum disorder 
ProteomicsDifferences in proteomic microglia from male and female brains
To determine the contribution at protein levels to the steady state of the cells in different sexes, we estimated the relative amounts of the microglia cells by mass spectrometry-based proteomics approach and further label-free quantification analysis (LFQ). We analysed the differences of protein ab...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-11-02 | MSV000081661 | MassIVE
ProteomicsNovel inhibitor(s) of NO-production for microglia and macrophages
We aimed to identify novel therapeutic compounds (small molecules) to target microglia and macrophage NO production. We set up a screen using a library of 30.000 drug-like compounds in collaboration with the FEM. Using a microglia cell line and primary microglia and macrophages, we identified one co...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-24 | PXD020613 | Pride
Compound ms Mouse Lc-ms Small molecule Exploris 480 No-synthesis 
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