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ProteomicsNovel inhibitor(s) of NO-production for microglia and macrophages
We aimed to identify novel therapeutic compounds (small molecules) to target microglia and macrophage NO production. We set up a screen using a library of 30.000 drug-like compounds in collaboration with the FEM. Using a microglia cell line and primary microglia and macrophages, we identified one co...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-24 | PXD020613 | Pride
Compound ms Mouse Lc-ms Small molecule Exploris 480 No-synthesis 
TranscriptomicsMessenger RNA profiling of bovine endometrium during the estrous cycle using a custom-made cDNA array
The endometrium provides optimal conditions for the transport of sperm to the oviduct, to the site of fertilization, and later on for the reception of the embryo. To study these changes on the level of gene expression, a messenger RNA expression profiling of endometrium tissue samples collected from...
ORGANISM(S): Bos taurus 
2010-05-27 | E-GEOD-8337 | biostudies-arrayexpress
ProteomicsSex-Specific Microglia Defects in the Neuroligin-4 Knock-Out Mouse Model of Autism Spectrum Disorder
Neuroligin-4 (NL4) loss-of-function mutations are strongly associated with monogenic heritable abnormalities linked with Autism Spectrum Disorder (ASD). NL4 mutation in mice causes ASD related alterations in both, the synaptic and behavioral phenotype. Since microglia closely regulate synaptic devel...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD024325 | Pride
Sex difference Gamma oscillation Estrogen Microglia Autism spectrum disorder 
UnknownThe KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers.
Not available
S-EPMC3352679 | biostudies-literature
TranscriptomicsThe MYC-MIZ1 interaction defines tumor identity
Medulloblastoma (MB) is the most common malignant brain tumor. MB is a cerebellar tumor that occurs mostly in children between the ages of 3-7 years but also in adults. Human MBs are classified into four subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3) and G4, each of which with distinc...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-64425 | biostudies-arrayexpress
TranscriptomicsBovine endometrium at day 18 of pregnancy after transfer of in vitro produced or somatic cell nuclear transfer embryos
Although somatic cell nuclear transfer (SCNT) cloning is more efficient in bovine than in all other species tested so far, there is a high rate of pregnancy failure that has been linked to structural and functional abnormalities of the placenta. We tested the hypothesis that these changes may origin...
ORGANISM(S): Bos taurus 
2009-03-12 | E-GEOD-13663 | biostudies-arrayexpress
TranscriptomicsOncogenic Myc levels activate and repress specific genes to form characteristic expression profiles in human tumors
Myc was depleted in HeLa cells (ATCC CRL-1934) with an shRNA and the resulting expression profile changes mapped via microarrays. This study is the equivalent of E-MTAB-1524 . E-MTAB-1524 has been replaced by E-MTAB-1886.
ORGANISM(S): Homo sapiens 
2014-07-11 | E-MTAB-1886 | biostudies-arrayexpress
OtherComprehensive proteome analysis of Actinoplanes sp. SE50/110 highlighting the location of proteins encoded by the acarbose and the pyochelin biosynthesis gene cluster.
Data from ProteomeXchange, PXD ID: PXD001497. Experiment: SW_Exo_G2, file: 130519_o3_p4_ao_SW_Exo_G2_8.mzml. Published as part of J Proteomics. 2015 Jul 1;125:1-16 . From the Abstract: {{i}} Acarbose is an α-glucosidase inhibitor produced by Actinoplanes sp. SE50/110 that is medically importan...
ORGANISM(S): Actinoplanes_sp_se50_110 
GPM32320019694 | GPMDB
Resource Reanalysis 
GenomicsAnalysis of MIZ1, MYC-ER and MYC-ERVD binding sites in MCF10A cells
Oncogenic levels of Myc expression sensitize cells to multiple apoptotic stimuli and this protects long-lived organisms from cancer development. How cells discriminate physiological from supra-physiological levels of Myc is largely unknown. Here we show that induction of apoptosis by Myc in breast e...
ORGANISM(S): Homo sapiens 
2015-07-10 | E-GEOD-59146 | biostudies-arrayexpress
TranscriptomicsDual regulation of Fbw7 function and oncogenic transformation by Usp28
Fbw7, the substrate recognition subunit of SCF(Fbw7) ubiquitin ligase, mediates turnover of multiple proto-oncoproteins and promotes its own degradation. Fbw7-mediated substrate degradation is antagonized by the Usp28 deubiquitinase. We now show, using knockout mice, that Usp28 preferentially deubiq...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-59354 | biostudies-arrayexpress
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