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ProteomicsSocial Network Architecture of Human Immune Cells Unveiled by Quantitative Proteomics
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not been established. Here, we applied high-resolution mass spectrometry-based proteomics to generate a publicly accessible pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-16 | MSV000081089 | MassIVE
ProteomicsSocial Network Architecture of Human Immune Cells Unveiled by Quantitative Proteomics
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not been established. Here, we applied high-resolution mass spectrometry-based proteomics to generate a publicly accessible pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-03 | MSV000096281 | MassIVE
TranscriptomicsDetermination of the transcription start sites of heterologous promoters in Actinoplanes sp. SE50/110 by 5'-end specific transcriptome sequencing
The promoter structure influences binding and clearance of RNA polymerase and therefore substantially influences expression of a gene. A promoter usually consists of a -10 and a -35-region, an extended -10-motif and A+T-rich upstream promoter elements. Most of these elements are optional, whereas th...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-26 | E-MTAB-8433 | biostudies-arrayexpress
TranscriptomicsComplex response on the level of the transcriptome by deletion of a local transcriptional repressor AmlR by RNAseq of the coding RNA
Actinoplanes sp. SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. Although maltose is an important building block of acarbose, the maltose/maltodextrin metabol...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-07 | E-MTAB-8404 | biostudies-arrayexpress
TranscriptomicsComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17) leading to formation of PML-RARA fusion, other genetic alterations have also been implicated in APL. ...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-77946 | biostudies-arrayexpress
TranscriptomicsHepatocyte-controlled availability of activated TGFb reprograms macrophage polarization affecting liver injury and regeneration
We describe a distinct macrophage population, whose presence in the liver during homoeostasis depends on recruitment signals mediated by the chemokine receptor CCR2. The identified polarization state of this population closely resembles that induced in co-culture experiments, where hepatocytes are r...
ORGANISM(S): Mus musculus 
2022-12-31 | E-MTAB-11727 | biostudies-arrayexpress
GenomicsWGSeq_HealthyHuman_DATA_SET_xmas_MB_2013_07_10 - samples
HSC73_clone: Bone marrow mononuclear cells from the healthy 73 years old female were thawed and labeled with Alexa-Fluor 488-conjugated anti-CD34 (581, Biolegend), Alexa-Fluor 700-conjugated anti-CD38 (HIT2, eBioscience), a cocktail of APC-conjugated lineage antibodies consisting of anti-CD4 (RPA-T4...
EGAD00001000666 | EGA
Genomicsrna_seq_data_freeze_march_2013_DATA_SET_MMML_2012_11_06 - samples
ICGC MMML-seq Data Freeze March 2013 transcriptome sequencing
EGAD00001000356 | EGA
GenomicsMMML_2012_11_06_Methylation450k_case - samples
DNA methylation analysis of 6 primary lymphoma samples
EGAD00010000377 | EGA
GenomicsWGSeq_RNAseq_ChIPseq_Cancer_ICGC_DATA_SET_xmas_MB_2013_07_10 - samples
Whole Genome Seq: Illumina HiSeq sequence data (with >30x coverage) were aligned to the hg19 human reference genome assembly using BWA (Li and Durbin, 2009); duplicate reads were removed from the final BAM file. No realignment or recalibration was performed. Paired-end RNA sequencing reads were mapp...
EGAD00001000664 | EGA
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