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ProteomicsTIA1 interactome from mouse cortex
The purpose of this experiment was to characterize the network of proteins that interact with TIA1, and to investigate whether tau exerts control over TIA1 protein interactions, TIA1 was immunoprecipitated from cortical brain tissue of 10 month-old WT (C57BL/6J), tau-/- and TIA1-/- mice. The specifi...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD003922 | Pride
Stress granule Map Translational regulation Alzheimer's disease Rna binding protein Rna metabolism Stress 
ProteomicsRepurposing Herpesvirus Protein ORF57 to Inhibit TDP-43 Aggregation
The integrated stress response (ISR) is a major element of translation control. The ISR is beneficial in responding to acute stresses, but in human disease a chronic, persistent stress response can contribute to the disease process. Many studies manipulate the ISR by targeting just one protein. Howe...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD039246 | Pride
Translational stress response Alzheimer’s disease Als Protein aggregation Tdp-43 
ProteomicsAlzheimer’s Disease-Associated circPDE4B Triggers Translation Stress Pathways
In the intricate landscape of Alzheimer’s disease (AD) pathology, circular RNAs(circRNA) are emerging as influential players, orchestrating crucial aspects of gene expression, synaptic plasticity, and neuronal function. In this study, we characterize the biological role of circPDE4B, a highly abunda...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD070615 | Pride
Gemin5 Stress Circpde4b Translation Alzheimer's disease 
UnknownThe heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype.
Not available
S-EPMC3433748 | biostudies-literature
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