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TranscriptomicsTranscription profiling of human HEK293 cells transfected with either wild type or delta exon 4 mutants of surfacant protein C
Mutations in the gene encoding surfactant protein C (SFTPC) have been linked to interstitial lung disease in children and adults. Expression of the index mutation, SP-Cdeltaexon4, in transiently transfected cells and type II cells of transgenic mice resulted in misfolding of the proprotein, activat...
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-2980 | biostudies-arrayexpress
UnknownRapid access to the core skeleton of the [3 + 2]-type dimeric pyrrole-imidazole alkaloids by triplet ketone-mediated C-H functionalization.
Not available
S-EPMC5880548 | biostudies-literature
TranscriptomicsHost and pathogen interaction: time course [C. albicans]
The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fis...
ORGANISM(S): Candida albicans 
2013-08-26 | E-GEOD-32117 | biostudies-arrayexpress
UnknownThe C-Terminal Transmembrane Domain of Cowpea Mild Mottle Virus TGBp2 Is Critical for Plasmodesmata Localization and for Its Interaction With TGBp1 and TGBp3.
Not available
S-EPMC9051516 | biostudies-literature
TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans rrf-3 and eri-1 mutants
RRF-3 and ERI-1 are first identified proteins required for accumulation of at least some endogenous secondary siRNAs in C.elegans. Genome wide gene expression analysis was performed on L4 stage rrf-3 and eri-1 mutant C. elegans to study effects caused by loss of these proteins. Mutant rrf-3 and eri-...
ORGANISM(S): Caenorhabditis elegans 
2008-06-16 | E-GEOD-8659 | biostudies-arrayexpress
UnknownModel-based projection of health and economic effects of screening for hepatitis C in Canada.
Not available
S-EPMC5621948 | biostudies-literature
TranscriptomicsDifferential gene expression in ahr-1 mutants compared to wild-type C. elegans
The aryl hydrocarbon receptor (AHR) functions in higher organisims in development, metabolism and toxic responses. Its Caenorhabditis elegans (C. elegans) ortholog, AHR-1, facilitates neuronal development, growth and movement. We investigated the effect of AHR mutation on the transcriptional profile...
ORGANISM(S): Caenorhabditis elegans 
2014-09-19 | E-GEOD-61537 | biostudies-arrayexpress
Unknown3DMMS: robust 3D Membrane Morphological Segmentation of C. elegans embryo.
Not available
S-EPMC6454620 | biostudies-literature
TranscriptomicsTransient expression of misfolded surfactant protein C
Mutations in the SFTPC gene associated with interstitial lung disease in human patients result in misfolding, endoplasmic reticulum (ER) retention, and degradation of the encoded surfactant protein C (SP-C) proprotein. To identify candidate genes involved in ER quality control of SP-C, HEK293 cells ...
ORGANISM(S): Homo sapiens 
2009-05-14 | E-GEOD-16054 | biostudies-arrayexpress
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