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TranscriptomicsSingle-cell RNA-seq of the human fetal lateral ganglionic eminence at 7, 9 and 11 post-conceptional weeks
Single-cell RNA-seq of the LGE between 7 and 11 pcw was used to uncover the different cell populations of the developing human striatum and how cells transition from early progenitors to mature medium spiny neuron (MSNs) together with the discovery of their unique coding and non-coding transcription...
ORGANISM(S): Homo sapiens 
2021-05-13 | E-MTAB-8894 | biostudies-arrayexpress
GenomicsEffects of Histone H3 depletion on nucleosome occupancy and positioning through the S. cerevisiae genome [single-end MNase-seq]
Experiments performed over the past three decades have shown that nucleosomes are transcriptional repressors. In Saccharomyces cerevisiae, depletion of histone H4 results in the genome-wide transcriptional de-repression of hundreds genes. The mechanism of de-repression is hypothesized to be rooted d...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-26 | E-GEOD-29291 | biostudies-arrayexpress
ProteomicsContractile work contributes to maturation of energy metabolism in hiPSC-derived cardiomyocytes
Energy metabolism is a key aspect of cardiomyocyte biology. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising tool for biomedical application, but they are immature and have not undergone metabolic shift related to early postnatal development. Cultivation of hiPSC...
ORGANISM(S): Homo sapiens (Human) 
2018-03-06 | PXD008205 | Pride
Human Ipsc Cardiomyocyte Engineered heart tissue 
TranscriptomicsTranscription profiling of pig aortic valve exposure to two levels of cyclic mechanical pressure reveals mechanosensitive signalling pathways
Multiple molecular and cellular mechanisms are associated with the initiation and progression of aortic valve disease. Alterations in ECM remodeling, increased expression of pro-inflammatory cytokines, calcification, lipid deposition and changes in valve cell phenotype have demonstrated roles in dev...
ORGANISM(S): Sus scrofa 
2009-03-25 | E-GEOD-15211 | biostudies-arrayexpress
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