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MetabolomicsNi-MOFs as a Simple and Effective Nanomedicine for ROS-Mediated Antibacterial Wound Healing via a Themoelectrocatalytic Process

Thermoelectrocatalytic nickel-based metal-organic frameworks (Ni-MOFs) autonomously generate reactive oxygen species (ROS) via human body-ambient temperature differences. They exhibit potent antibacterial activity against wound-infecting pathogens, and effectively promote infected skin wound heal...

2026-03-13 | MTBLS14045 | MetaboLights
ProteomicsPeptidomic analysis of bacterial protease activity in acute wound fluids
The clinical assessment of wound infection and related complications is challenging and the development of objective methods to measure wound status and predict healing outcomes is therefore essential. As bacterial protease activities play important roles in infection, analysis of changes in the wou...
ORGANISM(S): Homo sapiens (Human) 
2024-03-07 | PXD037047 | Pride
Human Lc-msms Wound fluids proteases Peptidome 
ProteomicsMethod development and characterization of the low molecular weight peptidome of human wound fluids
Peptidomic analysis and methodological development of characterization of low molecular weight peptidome of human wound fluids and plasma.Data on wound fluid peptides is also found in PXD023244
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023884 | Pride
Peptidomics orbitrap 
ProteomicsBioinformatic analysis of the wound peptidome reveals potential biomarkers and antimicrobial peptides
Peptidomic analysis and methodological development of characterization of low molecular weight peptidome of human wound fluids. Wounds are dynamic environments with high proteolytic activity. Therefore, the study of peptides, being the degradational product of proteins, are of interest when diagnosi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD023244 | Pride
Peptidomics wound fluid 
ProteomicsLongitudinal evaluation of biomarkers in wound fluids of venous leg ulcers treated with a protease-modulating wound dressing
Venous leg ulcers (VLU) represent a clinical challenge and impair the patient’s quality of life. Venous insufficiency is underlying the protracted healing. We report the protein expression pattern for biomarkers in VLU wound fluids and compare these with acute split-thickness wound fluids. Fifty-se...
ORGANISM(S): Homo Sapiens 
2023-08-22 | PXD025748 | panorama
ProteomicsIn Vivo Assessment of Protease Dynamics in Cutaneous Wound Healing by Degradomics Analysis of Porcine Wound Exudates
Proteases control complex tissue responses by modulating inflammation, cell proliferation and migration, and matrix remodeling. All these processes are orchestrated in cutaneous wound healing to restore the skin’s barrier function upon injury. Altered protease activity has been implicated in the p...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2014-12-19 | PXD001198 | Pride
N-terminome Wound healing Protease Tails Wound fluids 
ProteomicsComparative degradomics of porcine and human wound exudates unravels biomarker candidates for assessment of wound healing progression in trauma patients
Impaired cutaneous wound healing is a major complication in elderly people and patients suffering from diabetes with raising rates in industrialized countries. Heterogeneity of clinical manifestations hampers effective molecular diagnostics and decisions for appropriate therapeutic regimens. Using a...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2017-09-14 | PXD006674 | Pride
Impaired wound healing Negative pressure wound therapy Positional proteomics Tails Wound fluids Biomarker 
ProteomicsBlinded rerun of infected and uninfected pig wound fluids
This is a blinded rerun of 12 pig wound fluid samples from the study at PXD048892, looking at differences in wound fluid peptidomes based on infecting pathogen.The raw data alongside code for easily loading and processing the data and creating relevant figures is available at https://github.com/Fred...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-13 | PXD055074 | Pride
Wound fluid Proteomics Infection Porcine Pig 
TranscriptomicsmiRNA regulation in diabetes associated impaired wound healing
Circulating miRNAs constitute a novel class of disease biomarkers, which are altered in diabetes but the effect of diabetes associated inflammation as seen in chronic wounds is unknown. We here compared the miRNA pattern in diabetic patients in presence or absence of chronic wound with PAD. The clin...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-49885 | biostudies-arrayexpress
ProteomicsPeptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data
Recent advances in mass spectrometry-based peptidomics have catalyzed the identification and quantification of thousands of endogenous peptides across diverse biological systems. However, the vast peptidomic landscape generated by proteolytic processing poses several challenges for downstream analys...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2024-07-13 | PXD048892 | Pride
Peptidomics Wound fluid Peptides Human Infection Porcine 
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