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TranscriptomicsTranscription profiling of human CEBPA mutant and CEBPA silenced AML and in T-ALL
Acute Myeloid Leukemia (AML) is a heterogeneous disease from the molecular and biological standpoints, and even patients with a specific gene expression profile may present clinical and molecular heterogeneity. We studied the epigenetic profiles of a cohort of patients that shared a common gene expr...
ORGANISM(S): Homo sapiens 
2009-01-24 | E-GEOD-14479 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in CEBPA mutant and CEBPA silenced AML
Acute Myeloid Leukemia (AML) is a heterogeneous disease from the molecular and biological standpoints, and even patients with a specific gene expression profile may present clinical and molecular heterogeneity. We studied the epigenetic profiles of a cohort of patients that shared a common gene expr...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-14417 | biostudies-arrayexpress
TranscriptomicsCCAAT/enhancer-binding protein alpha target genes in myeloid progenitor cells uncovered by chromatin IP
CCAAT/enhancer-binding protein alpha (C/EBPM-NM-1) is a lineage-specific transcription factor that directs development of granulocytes. To obtain insights into the genome-wide transcriptome of wild type C/EBPM-NM-1, we have performed chromatin immunoprecipitation on DNA promoter microarrays (ChIP-ch...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-19321 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CEBPA double-, single-mutant and CEBPA wild type AML
A previously predictive CEBPA double mutant (CEBPAdm) signature was hampered by the recently reported CEBPA silenced AML cases that carry a similar gene expression profile (GEP). Two independent AML cohorts were used to train and evaluate the predictive value of the CEBPAdm signature in terms of sen...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-22845 | biostudies-arrayexpress
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