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MetabolomicsMaternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods
Hormones play critical roles in facilitating pregnancy progression and the onset of parturition. Several classes of environmental contaminants, including fine particulate matter (PM2.5) and ambient temperature, have been shown to alter hormone biosynthesis or activity. However, epidemiolo...
2024-06-27 | MTBLS2245 | MetaboLights
TranscriptomicsGlobal changes in Staphylococcus aureus gene expression in human blood provide insight into mechanisms of immune evasion and virulence
Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as USA300. Although progress has been made, our understanding of the S. aureus molecules that promote bacteremia and survival in human blood is ...
ORGANISM(S): Staphylococcus aureus 
2011-08-25 | E-GEOD-25454 | biostudies-arrayexpress
UnknownCardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.
Not available
S-EPMC5664535 | biostudies-literature
UnknownDNA methylation changes in African American women with a history of preterm birth from the InterGEN study.
Not available
S-EPMC8418749 | biostudies-literature
UnknownRandomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA).
Not available
S-EPMC5824534 | biostudies-literature
TranscriptomicsSLE serum induced transcripts regulated by IFNa2b
To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-M-NM-12b) in vitro. RNA was extracted at 6 hrs and the expression data was normalized to that of monocytes cultured with medium. Blood monocytes isolated f...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46921 | biostudies-arrayexpress
TranscriptomicsTranscripts induced by recombinant IFNa in healthy blood monocytes at different time points
To explore the full extent of IFN-regulated transcriptional changes, we exposed monocytes from two healthy donors to recombinant type I IFN (IFN-M-NM-12b) in vitro. RNA was extracted at different incubation times (1, 6, 24, 48 and 72 hrs) and the expression data was normalized to that of monocytes c...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46911 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed transcripts in SLE blood monocytes
To better characterize the molecules that could potentially confer antigen presenting capacity to SLE monocytes, we assessed their gene expression profile. Blood monocytes from five healthy controls and five pediatric SLE patients were isolated using CD14+ selection. Because drugs used to treat SLE ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46907 | biostudies-arrayexpress
TranscriptomicsTranscripts differentially expressed in healthy blood mDCs compared to healthy monocytes
To directly compare the SLE monocyte transcriptional program with that of blood mDC precursors, we purified lineage HLA-DRhighCD11chigh mDCs and CD14+ monocytes from the blood of five healthy donors. Their gene expression profiles were then compared to those of blood SLE monocytes. An unsupervised c...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46913 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed transcripts in SLE blood monocytes according to their capacity to induce mixed lymphocytic reaction
We screened SLE monocytes from 19 SLE patients and selected 4 that induced CD4+ T cell proliferation in vitro and 4 that did not. CFSE labeled CD4-T cells (105) were incubated with SLE monocytes (2 x 104). Cells were harvested at 6 hours for RNA extraction. We screened SLE monocytes from 19 SLE pati...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-46917 | biostudies-arrayexpress
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