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ProteomicsDe novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defense
De novo pyrimidine biosynthesis is achieved by cytosolic enzymes, CAD and UMPS, and mitochondrial DHODH. However, how these enzymes are orchestrated remains enigmatical. Here, we show that cytosolic aspartate-producing GOT1 clusters with CAD and UMPS. This cytosolic cluster then connects with DHODH,...
ORGANISM(S): Homo Sapiens 
2023-03-22 | PXD041017 |
TranscriptomicsComparison of DNA methylation profiles in diploid and transformed tetraploid MEF cells
We propose that tetraploidy induces epigentic changes including DNA methylation due to the abnormal chromatin in the cells. To test our hypothesis, we employed methylated CpG island recovery assay (MIRA) assisted microarray to determine the DNA methylation profiles in both diploid and tetraploid cel...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-18814 | biostudies-arrayexpress
ProteomicsEGFR-TKI-down-regulated proteins in HCC827 cells
EGFR mediates stabilities of a wide spectrum of proteins. Treatment of the cells with EGFR tyrosine kinase inhibitors (EGFR-TKIs) leads to degradation of these proteins. To define the proteins and corresponding pathways of EGFR-stabilized proteins, we use mass spectrum to quantify the protein level...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD050420 | Pride
Human egfr mutated lung cancer cells 
TranscriptomicsComparison of gene expression profiles in diploid and transformed tetraploid MEF cells
We propose that abnormal DNA content in tetraploid cells can alter the gene expression profile, contributing to the cellular transformation. To test this hypothesis, we employ mRNA microarray to compare the gene expression profile in transformed tetraploid cells with that in the parent diploid cells...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-18802 | biostudies-arrayexpress
UnknownCanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects.
Not available
S-EPMC8288037 | biostudies-literature
ProteomicsThe Matrisome Reveals the Characterization of Skin Keloid Microenvironment
Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis. In this study, the dermal EC...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD019052 |
ProteomicsTime-resolved extracellular matrix atlas of the developing human skin dermis
Skin aging is a physiological problem that remains a concern. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging; however, changes in ECM characteristics and molecules that are secreted to the extracellular space and involved in the formation of ...
ORGANISM(S): Homo Sapiens 
2022-11-28 | PXD016440 |
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