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ModelsMiao2010 - Innate and adaptive immune responses to primary Influenza A Virus infection_1_1
Miao2010 - Innate and adaptive immune responses to primary Influenza A Virus infection This model is described in the article: Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus. Miao H, Hollenbaugh JA, Zand MS, ...
2024-09-02 | BIOMD0000000546 | BioModels
OtherSILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells.
Data from ProteomeXchange, PXD ID: PXD000773. File: zhanghongyu_20110913_13.mzml. Published as part of . From the Abstract: {{i}} Activated hepatic stellate cell (HSC) is the main myofibroblast cell in the liver fibrosis (LF). An important characteristic of the recovery of LF is not only the apopto...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310002866 | GPMDB
Resource Reanalysis 
UnknownA scalable algorithm for structure identification of complex gene regulatory network from temporal expression data.
Not available
S-EPMC5294888 | biostudies-literature
TranscriptomicsExpression data from QY and QYRC cell lines
We superinfected a hepatocellular carcinoma (HCC) cell line (QGY-7703,QY) with oncolytic parvovirus H1 (H-1PV) and acquired a group of resistant cells QYRC. Previous studies suggested that cells surviving H-1PV superinfection should behave somewhat similarly to normal cells. When compared with the Q...
ORGANISM(S): Homo sapiens 
2016-01-12 | E-GEOD-76754 | biostudies-arrayexpress
ProteomicsSILAC-based Quantitative Proteomic Analysis of Secretome between Activated and Reverted Hepatic Stellate Cells
Activated hepatic stellate cell (HSC) is the main myofibroblast cell in the liver fibrosis(LF). An important characteristic of the recovery of LF is not only the apoptosis of activated HSCs but also reversal of myofibroblast-like phenotype to a quiescent-like phenotype. Understanding the changes of ...
ORGANISM(S): Homo sapiens (Human) 
2014-08-11 | PXD000773 | Pride
Lx-2  activation  reversion  secretome 
ProteomicsMycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Interferon (IFN)-γ-producing CD8+ T cells are involved in control of Mycobacterium tuberculosis (Mtb) infection, in part by promoting antimicrobial activities of macrophages. Whether Mtb counters these responses, particularly during the hypoxic conditions that arise within granulomas during infectio...
ORGANISM(S): Mycobacterium tuberculosis OFXR-32 
2024-08-10 | PXD050258 | Pride
Mycobacterium tuberculosis  d-serine  rv0884c  wdr24  mtorc1  cd8+ t cell 
TranscriptomicsExpression profiling reveals novel pathways in the transformation of melanocytes to melanomas. II
Spotted oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma cells...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4576 | biostudies-arrayexpress
ProteomicsIcariside II restores vascular smooth muscle cell contractile phenotype by enhancing focal adhesion signaling pathway in rat vascular remodeling model
In this work, we investigated the pharmacological effects of ICS-II on VSMC phenotypic transition and reveal the underlying mechanisms through in vivo and in vitro experiments. Our results highlight the thera-peutic benefits of ICS-II targeting VSMC phenotypic transition and sup-port the potential o...
ORGANISM(S): Rattus Norvegicus 
2022-05-05 | PXD033724 |
ProteomicsGSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1
Age-related obesity is a growing public health concern since it contributes to a multitude of metabolic disorders, yet its mechanisms remain poorly defined. Herein, we report that S-nitrosoglutathione reductase (GSNOR), a pivotal enzyme for de-nitrosation, significantly increased in adipose tissues...
ORGANISM(S): Mus <genus> 
2025-12-25 | PXD072412 |
ProteomicsHypothalamic malate dehydrogenase 2 (MDH2) modulates systemic glucose metabolism through oxytocin-mediated thermogenesis
Bariatric surgery improves hyperglycemia in obesity and type 2 diabetes (T2D), yet its central mechanisms remain unclear. Through cerebrospinal fluid proteomic profiling of rats, we identify reduced central malate dehydrogenase 2 (MDH2) levels that correlate with surgery-induced restoration of normo...
ORGANISM(S): Rattus Norvegicus 
2025-12-19 | PXD072275 |
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