Sort   by:  
 Page size 
UnknownInhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects.

Objective

As a key member of the transient receptor potential (TRP) superfamily, TRP canonical 3 (TRPC3) regulates calcium homeostasis and contributes to neuronal excitability. Ablation of TRPC3 lessens pilocarpine-induced seizures in mice, suggesting that TRPC3 inhibition might represent a ...
S-EPMC9007831 | biostudies-literature
UnknownAnalysis of Postsurgical Health-Related Quality of Life and Quality of Voice of Patients With Laryngeal Carcinoma.
This study aims to analyze the postsurgical health-related quality of life (HRQOL) and quality of voice (QOV) of patients with laryngeal carcinoma with an expectation of improving the treatment and HRQOL of these patients. Based on the collection of information of patients with laryngeal carcinoma r...
S-EPMC4706258 | biostudies-literature
UnknownJW-1-283 inhibits melanoma tumor growth via stabilization of the p53 pathway.
Not available
S-EPMC10808915 | biostudies-literature
MetabolomicsMetabolite profiling of Arabidopsis mutants of enzymes of lower glycolysis
We have previously shown that in Arabidopsis the three enzymes of lower glycolysis phosphoglycerate mutase (PGAM), enolase and pyruvate kinase form a complex which play an important role in co-sub-cellar localization the mitochondria to the chloroplast. Given that their metabolites of these mutants,...
2022-10-10 | MTBLS4066 | MetaboLights
UnknownAssociation between MRI indicators of the glymphatic system and cognition in high-risk populations for Alzheimer's disease.

Background

Using the Diffusion Tensor Image Analysis Along the Perivascular Space (ALPS) method and perivascular space (PVS) burden to study glymphatic function in high-risk Alzheimer's disease (AD) populations, this research investigates the correlation between ALPS index and PVS volume wit...
S-EPMC12934294 | biostudies-literature
UnknownLife extension factor klotho regulates behavioral responses to stress via modulation of GluN2B function in the nucleus accumbens.
Klotho is a life extension factor that has the ability to regulate the function of GluN2B-containing N-methyl-D-aspartate receptors (NMDARs), whose dysfunction in the nucleus accumbens (NAc) underlies critical aspects of the pathophysiology of major depression. Here, we study the functional relevanc...
S-EPMC9283408 | biostudies-literature
UnknownPathologic complete response after neoadjuvant tislelizumab and chemotherapy for Pancoast tumor: A case report.
A 60-year-old man was hospitalized because of numbness and weakness in the right upper limb. Magnetic resonance imaging revealed a large mass in the right upper lobe invading the right eighth cervical and first thoracic nerve root. Biopsy pathology confirmed primary lung adenocarcinoma with a clinic...
S-EPMC8046127 | biostudies-literature
ProteomicsExtracellular vesicles secreted from senescent cancer cells promote colorectal cancer progression through SERPINE1
By the iTRAQ-based quantitative proteomics, we assessed the protein cargos inside EVs secreted from colorectal cancer cells
ORGANISM(S): Homo sapiens (Human) 
2024-04-06 | PXD047062 | Pride
Extracellular vesicles Colorectal cancer cells Itraq Senescence 
UnknownUVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response.
Brusatol (BR) is a potent inhibitor of Nrf2, a transcription factor that is highly expressed in cancer tissues and confers chemoresistance. UVA-generated reactive oxygen species (ROS) can damage both normal and cancer cells and may be of potential use in phototherapy. In order to provide an alternat...
S-EPMC5835260 | biostudies-literature
UnknownInvestigating the relationship between depression and breast cancer: observational and genetic analyses.

Background

Both depression and breast cancer (BC) contribute to a substantial global burden of morbidity and mortality among women, and previous studies have observed a potential depression-BC link. We aimed to comprehensively characterize the phenotypic and genetic relationships between dep...
S-EPMC10161423 | biostudies-literature
Sort   by:  
 Page size