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ProteomicsLabel-free proteome analysis of small extracellular vesicles (sEV) expressing different HRS mutants.
Label-free proteome analysis of small extracellular vesicles (sEV) derived from WM9 cells expressing different HRS mutants: wild type (HRSWT), phospho-deficient (HRSS345A), and phospho-mimetic mutant HRS (HRSS345D).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-16 | MSV000088846 | MassIVE
UnknownMultiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease
Not available
S-SCDT-10_1038-S44321-024-00129-8 | biostudies-other
UnknownYY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation.
Not available
S-EPMC7732823 | biostudies-literature
ProteomicsHuh-7 exosomes and HBV
Hepatitis B virus (HBV) infection could cause hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV-mediated pathogenesis is only partially understood, but X protein (HBx) reportedly possesses oncogenic potential. Exosomes are small membrane vesicles with diverse functions released by various...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080794 | MassIVE
ProteomicsGlobal quantitative analysis of proteomic of mice with liver fibrosis based on DIA and PRM technology
Liver fibrosis (LF) is a kind of progressive liver injury reaction. The goal of this study was to achieve a more detailed understanding of the molecular changes in response to CCl4-induced LF through the identification of a differentially expressed liver proteomic. A total of 302 differentially expr...
ORGANISM(S): Mus Musculus 
2023-03-14 | PXD040876 |
GenomicsWhole Exome Sequencing of Chronic Lymphocytic Leukemia

The somatic genetic basis of chronic lymphocytic leukemia (CLL), a common and clinically heterogenous adult leukemia, remains poorly understood. Massively parallel sequencing technology now provides a method for systematic discovery of genetic alterations that underlie disease, and for uncovering...

phs000435.v1.p1 | EGA
TranscriptomicsGene expression analysis of induced pluripotent stem cells from aneuploid chromosomal syndromes
Background:Human aneuploidy is the leading cause of early pregnancy loss, mental retardation, and multiple congenital anomalies. Due to the high mortality associated with aneuploidy, the pathophysiological mechanisms of aneuploidy syndrome remain largely unknown. Previous studies focused mostly on w...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-GEOD-49247 | biostudies-arrayexpress
TranscriptomicsExpression data from normal B cells and chronic lymphocytic leukemia B cells -- with/without treatment of Wnt3a
Wnt pathway is dysregulated in CLL-We characterized Wnt pathway gene expression in normal B and CLL-B cells and identified Wnt targets in normal B and CLL-B cells through this data set. In this dataset, we included normal B cells and CLL-B cells for Wnt pathway gene expression. This leads to the ide...
ORGANISM(S): Homo sapiens 
2013-08-29 | E-GEOD-31048 | biostudies-arrayexpress
ProteomicsPlasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specifi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-09-19 | MSV000084344 | MassIVE
ProteomicsImmunoprecipitates of KDM1A in HepG2 cells with stably overexpressed KDM1A
KDM1A requires an adaptor protein with specific DNA-binding activity to recognize chromatin sequence. We constructed HepG2 cells stably overexpressing KDM1A-Flag tag using lentivirus. We performed Co-IP with Flag-gel and we used LC-MS to determine the immunoprecipitates of KDM1A.
ORGANISM(S): Homo Sapiens 
2023-05-19 | PXD043284 |
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