Label-free quantitative proteomics was applied to screen differentially expressed proteins in QG-MF-treated A549 lung cancer cells. Functional enrichment analysis and in vitro/in vivo validation confirmed the regulation of the p53/p21 signaling cascade. All mass spectrometry raw data and processed a...
The tumor suppressor gene RASSF1A (Ras association domain family protein 1A) coding for a microtubule stabilizing protein is epigenetically silenced in most human cancers. As a binding partner of the kinases MST1 and MST2, the mammalian orthologues of the Drosophila Hippo kinase, RASSF1A is a potent...
