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ProteomicsProteomic Characterization of Epithelial Ovarian Cancer Delineates Molecular Signatures and Therapeutic Targets in Distinct Histological Subtypes
Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear. Here, we undertake comprehensive proteomic profiling of 80 CCC, 79 EC, 80 SC, and 30 contr...
ORGANISM(S): Homo sapiens (Human) 
2023-10-30 | PXD033741 | Pride
Epithelial ovarian cancer proteomics histological subtype tumor biomarkers drug target 
ProteomicsIdentification of targets of DBIC
Pyroptosis is a type of lytic cell death executed by members of the gasdermin family. It has been demonstrated that induction of pyroptosis can effectively inhibit tumor growth, which implicates a new strategy for clinical tumor therapy, especially for those tumors (such as melanoma) that are insens...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD054435 | Pride
Nuclear receptor nur77  heme  granzyme b  gsdmc  pyroptosis 
ProteomicsIdentify Novel Iron–Transporting Proteins in Streptococcus pneumoniae
Streptococcus pneumoniae (S. pneumoniae) is a major human pathogen causing morbidity and mortality worldwide. Efficiently acquiring iron from the environment is critical for S. pneumoniae to sustain growth and cause infection. There are only three known iron-uptake systems in Streptococcal species r...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2018-10-26 | PXD003313 | Pride
Streptococcus pneumoniae Iron–transporting proteins Proteomics 
UnknownImpact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis.
Not available
S-EPMC7559685 | biostudies-literature
UnknownThe complete chloroplast genome of Mexican marigold (Tagetes erecta L., Asteraceae).
Not available
S-EPMC7707445 | biostudies-literature
UnknownMORF4L2 induces immunosuppressive microenvironment and immunotherapy resistance through GRHL2/MORF4L2/H4K12Ac/CSF1 axis in triple-negative breast cancer.
Not available
S-EPMC11715975 | biostudies-literature
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownDisruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage.
Not available
S-EPMC12711971 | biostudies-literature
UnknownProteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes.
Not available
S-EPMC10684593 | biostudies-literature
UnknownImprovement cues of lesion absorption using the adjuvant therapy of traditional Chinese medicine Qinbudan tablet for retreatment pulmonary tuberculosis with standard anti-tuberculosis regimen.
Not available
S-EPMC7203794 | biostudies-literature
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