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Antibiotic resistance is increasingly becoming a serious challenge to public health. The regulation of metabolism by post-translational modifications (PTMs) has been widely studied; however, the comprehensive mechanism underlying the regulation of acetylation in bacterial resistance against antibiot...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2022-10-14 | PXD030283 | Pride
In summary, this study shows advantages of the CIP-R in the survival, drug resistance and virulence in iron restricted condition. DIA-based proteomics study combined with biochemical validation showed that CIP-R saves the energy by storing the glucose and increases the cell wall synthesis. Moreover,...
ORGANISM(S): Staphylococcus aureus 
2021-03-31 | PXD021692 | Pride
To further identify endogenous substrates of SPD_0839 and establish its regulatory network, quantitative proteomic analysis was performed on the spd_0839+ and p169 strains.
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2026-03-09 | PXD058867 | Pride
Abstract The infection of drug resistant bacteria seriously threats to public health, which makes it more urgent to find novel antibacterial compounds. Compared with traditional development approaches, drug repurposing provides a faster and more effective strategy to find new antimicrobial agents....
ORGANISM(S): Staphylococcus aureus 
2022-03-10 | PXD029546 | Pride
The rate-limiting enzyme of salvage pathway for NAD+ synthesis, NAMPT, is aberrantly overexpressed in a variety of tumor cells and is a poor prognosis factor for patient survival. NAMPT plays a major role in tumor cell proliferation, acting concurrently as an NAD+ synthase and unexpectedly, an extra...
ORGANISM(S): Homo Sapiens 
2022-01-24 | PXD031185 |
The rate-limiting enzyme of salvage pathway for NAD+ synthesis, NAMPT, is aberrantly overexpressed in a variety of tumor cells and is a poor prognosis factor for patient survival. NAMPT plays a major role in tumor cell proliferation, acting concurrently as a NAD+ synthase and unexpectedly, an extrac...
ORGANISM(S): Homo Sapiens 
The significantly enriched proteins in growth plate-epiphysis interface compared to growth plate and epiphysis and the significantly enriched proteins in growth plate-metaphysis interface compared to growth plate and metaphysis;
ORGANISM(S): Homo Sapiens 
2025-01-16 | PXD059908 |
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