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UnknownImplications of cardiac markers in risk-stratification and management for COVID-19 patients.
Not available
S-EPMC8074282 | biostudies-literature
GenomicsAge related Macular Degeneration (AMD)-- Michigan, Mayo, AREDS, Pennsylvania (MMAP) Cohort Study: A Joint Genome Wide Association Study

Age-related Macular Degeneration (AMD) is a leading cause of incurable blindness in people over the age of 65. AMD is a late-onset multi-factorial neurodegenerative disease and its pathogenesis involves interaction of genetic and environmental factors. Several chromosomal regions have been as...

phs000182.v2.p1 | EGA
Proteomics,Multiomicsembryo_proteome
We collected over 8000 mouse embryos of each developmental stage (zygote, 2-cell, 4-cell, 8-cell, morula, blastocyst) and performed tandem mass tag (TMT)-based quantitative mass spectrometry and identified nearly 5000 proteins for each stage. In-depth analysis indicates that protein expression profi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-12-10 | MSV000079417 | MassIVE
ProteomicsInhibition of a novel CLK1-THRAP3-PPARγ axis improves insulin sensitivity
CLK1 plays a critical role in controlling energy expenditure through the CLK1-Thrap3-PPARγ axis.
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-08-16 | PXD027958 |
Proteomics4D-diaXLMS: Proteome-wide Four-Dimensional Data-Independent Acquisition Workflow for Cross-linking Mass Spectrometry
Cross-linking Mass Spectrometry (XL-MS) is a powerful tool for examining protein structures and interactions. Nevertheless, anal-ysis of low-abundance cross-linked peptides is often limited in data-dependent acquisition (DDA) mode due to its semistochastic nature. To address this issue, we introduce...
ORGANISM(S): Homo Sapiens Saccharomyces Cerevisiae 
2023-06-26 | PXD043282 |
ProteomicsQuantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis
Systemic sclerosis (SSc) is a perplexing autoimmune disorder, characterized by mysterious causes, high mortality rates, and a lack of effective treatments. The role of abnormal glycosylation in the onset of autoimmune diseases has been recognized for some time. Nonetheless, the intricate details of ...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057509 |
ProteomicsN-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease
Anti-synthetase syndrome (ASS), a subtype of idiopathic inflammatory myopathy (IMM), is characterized by distinctive skin rashes, proximal muscle weakness, and interstitial lung disease (ILD). The etiology of ASS remains largely unknown, and patients endure a poor quality of life and are prone to pu...
ORGANISM(S): Homo Sapiens 
2024-11-20 | PXD058077 |
ProteomicsHigh-Coverage Four-Dimensional Data-Independent Acquisition Proteomics and Phosphoproteomics Enabled by Deep Learning-Driven Multi-Dimensional Prediction
Here, a workflow of 4D DIA proteomics by using the predicted multi-dimensional in silico library was established. A deep learning model Deep4D that could high-accurately predict the CCS and RT of both the unmodified and phosphorylated peptides was developed, which is the model based on self-attentio...
ORGANISM(S): Homo Sapiens Mus Musculus Saccharomyces Cerevisiae 
2023-04-19 | PXD034553 |
ProteomicsHDL Quality Features Revealed by Proteome-Lipidome Connectivity are Associated with Atherosclerotic Disease
The “quality” rather than “quantity” of lipoprotein particles is more relevant to cardiovascular diseases (CVD), since lipoprotein particles are highly heterogeneous. However, the targeted separation, detection, and exploration of the heterogeneous on omic-scale for lipoprotein remain challenging an...
ORGANISM(S): Homo Sapiens 
2020-02-15 | PXD017529 |
ProteomicsHDL quality feature revealed by proteome-lipidome connectivity are associated with atherosclerotic disease
Lipoprotein, especially high density lipoprotein (HDL) particles are composed of multiple heterogeneous subgroups containing various proteins and lipids. The molecular distribution among these subgroups is closely related to cardiovascular disease (CVD). Here, we established high-resolution proteomi...
ORGANISM(S): Oryctolagus Cuniculus Homo Sapiens 
2021-09-03 | PXD028209 |
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