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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsDeveloping a Novel and Integrative Method to Systematically Investigate the Stability of N-Terminal Proteoforms
Protein N-terminal proteoforms, which include both N-terminal modifications and sequence variation arising from processes such as proteolytic cleavage, are common in cells and have been reported to significantly impact protein stability. Systematically examining the correlation between these N-termi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD057760 | Pride
Thermal proteome profiling N-terminal acetylation N-terminome Thermal stability difference Terminal amine isotopic labeling of substrates Tails Tpp N-terminal proteoform 
ProteomicsCirculating proteomic panels for diagnosis and risk stratification of acute-on-chronic liver failure in patients with viral hepatitis B
Circulating proteomic panels for diagnosis and risk stratification of acute-on-chronic liver failure in patients with viral hepatitis B
ORGANISM(S): Homo Sapiens 
2025-11-14 | PXD070798 |
ProteomicsSpatiotemporally-resolved mapping of extracellular proteomes via in vivo-compatible TyroID
Extracellular proteins play pivotal roles in both intracellular signaling and intercellular communications in health and disease. While recent advancements in proximity labeling (PL) methods, such as peroxidase- and photocatalyst-based approaches, have facilitated the resolution of extracellular pro...
ORGANISM(S): Homo Sapiens Mus Musculus Bos Taurus 
2024-11-21 | PXD054796 |
ProteomicsCREB3 suppresses hepatocellular carcinoma progression by depressing AKT signaling through competitively binding with INSR and transcriptionally activating RBM38
CREB3 is suggested to interact with many proteins. We explored the potential binding proteins using co-IP.
ORGANISM(S): Homo Sapiens 
PXD052604 |
Proteomicsdevelopment of prognostic biomarkers for HBV-related acute-on-chronic liver failure
development of prognostic biomarkers for HBV-related acute-on-chronic liver failure
ORGANISM(S): Homo Sapiens 
2020-03-07 | PXD017928 |
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
PXD056593 |
ProteomicsDDX5-sIL-36R in keratinocytes controls skin inflammation
The DEAD-box (DDX) proteins function in diverse cellular processes including RNA alternative splicing, and are linked to immune-mediated diseases. However, little is known about the roles of DDXs in skin inflammatory diseases. Here, we show that DDX5, one of the founding members of the DDX RNA helic...
ORGANISM(S): Homo Sapiens 
PXD021379 |
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