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ProteomicsThe proteome of neuromelanin granules in dementia with Lewy bodies
Neuromelanin granules (NMGs) are organelle-like structures present in the human substantia nigra pars compacta. Besides neuromelanin, NMGs contain proteins, lipids and metals. As NMG-containing dopaminergic neurons are preferentially lost in Parkinson’s disease and dementia with Lewy bodies (DLB), i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD035310 | Pride
Proteomics Stress granules Substantia nigra pars compacta Dementia with lewy bodies Neurodegeneration Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD033381 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsSchizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons
Large-scale genomic screenings greatly advanced our understanding of the genetic basis of schizophrenia. However, how this translates into neurobiological functioning is not clear. Therefore, we aimed to characterize the function of robust susceptibility gene zinc finger protein 804A (ZNF804A), usin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD047788 | Pride
Ribosomes Compartment seperation assay Schizophrenia Data-independent acquisition Synaptogenesis 
UnknownT-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals.
Not available
S-EPMC10652962 | biostudies-literature
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