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TranscriptomicsInvolvement of the brain renin-angiotensin system in the effects of maternal separation
The postnatal development of the mouse is characterized by a stress hyporesponsive period (SHRP), where basal corticosterone levels are low and responsiveness to mild stressors is reduced. Maternal separation is able to disrupt the SHRP and is widely used to model early trauma. In this study we aime...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-14687 | biostudies-arrayexpress
TranscriptomicsNovel aspects of the transcriptional stress response in the paraventricular nucleus of the mouse strains DBA/2J and C57BL/6J
The pivotal role of stress in the precipitation of psychiatric diseases is generally accepted. To further elucidate the underlying molecular mechanisms, gene networks and signalling cascades, we investigated the impact of an acute stressor, forced swimming, on the gene expression profile in the hypo...
ORGANISM(S): Mus musculus 
2010-10-20 | E-GEOD-20877 | biostudies-arrayexpress
TranscriptomicsEbf2-GFP in IEO cells
Comparison of Ebf2-expressing bone marrow mesenchymal cells from Ebf2-GFP heterozgous and Ebf2-GFP homozygous (=knock-out) mice
ORGANISM(S): Mus musculus 
2017-12-17 | E-MTAB-2254 | biostudies-arrayexpress
TranscriptomicsMusashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice
We have used a retroviral integration screen to search for novel genes that regulate hematopoietic stem cell (HSC) function. One of the genes that conferred HSC dominance when overexpressed due to an adjacent retroviral insertion was Musashi 2 (Msi2), an RNA binding protein that can act as a transla...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29432 | biostudies-arrayexpress
TranscriptomicsMurine corticotroph pituitary AtT-20 cells: Crh treatment time course
As the Crh-system and the HPA-axis are known to be crucially involved in the onset, development and maintainance of psychiatric disorders like anxiety and depression and regulate the behavioural and endocrine stress responses the further analysis of Crhr1-dependent signaling cascades is essential to...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-13156 | biostudies-arrayexpress
TranscriptomicsMAPK Signaling Determines Anxiety in the Juvenile Mouse Brain but Depression-like Behavior in Adults
MAP kinase signaling has been implicated in brain development, long-term memory, and the response to antidepressants. Inducible Braf knockout mice enabled us to unravel a new role of neuronal MAPK signaling for emotional behavior. Braf mice that were induced during adulthood showed normal anxiety bu...
ORGANISM(S): Mus musculus 
2012-04-18 | E-GEOD-33618 | biostudies-arrayexpress
TranscriptomicsGene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are gener...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13588 | biostudies-arrayexpress
TranscriptomicsIndividual susceptibility to chronic stress is modulated by AMPA receptor function
Chronic stress is a key risk factor for a variety of diseases, but the determinants of individual stress susceptibility are still unclear. Using a recently developed paradigm for chronic social stress in mice we identified animals that were resistant or susceptible to the persistent effects of chron...
ORGANISM(S): Mus musculus 
2010-10-25 | E-GEOD-11211 | biostudies-arrayexpress
TranscriptomicsDickkopf 3 Promotes the Differentiation of Substantia Nigra Dopaminergic Neurons In Vivo and from Pluripotent Stem Cells In Vitro
WNT1/beta-catenin signaling plays a crucial role in the generation of mesodiencephalic dopaminergic (mdDA) neurons including the Substantia nigra pars compacta (SNc) subpopulation, whose degeneration is a hallmark of Parkinson’s Disease (PD). However, the precise functions of WNT/beta-catenin signal...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-58813 | biostudies-arrayexpress
TranscriptomicsInvestigating the first genomic response to stress – insights into the etiology and pathophysiology of major depression
While exposure to adverse life events and subsequent dysregulation of the stress hormone response broadly confer risk for depression, the specific molecular mechanisms mediating this risk are poorly understood. Through pharmacologic activation of the stress hormone response in blood cells we demonst...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-46743 | biostudies-arrayexpress
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