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TranscriptomicsExpression data from wild type, Ring1B-/-, Eed-/-, and Ring1B/Eed double deficient mouse ES cells
Polycomb complexes establish chromatin modifications for maintaining gene repression and are essential for embryonic development in mice. Here we use pluripotent embryonic stem (ES) cells to demonstrate an unexpected redundancy between Polycomb repressive complex 1 (PRC1) and PRC2 during the formati...
ORGANISM(S): Mus musculus 
2009-11-30 | E-GEOD-19076 | biostudies-arrayexpress
GenomicsREST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells
Genome-wide analysis of REST and Polycomb binding in Rest-/- and Eed-/- mouse embryonic stem (mES) cells showed that Rest was required for PRC1 recruitment to a subset of Polycomb regulated neuronal genes. Furthermore, we found that PRC1 can be recruited to Rest binding sites independently of CpG is...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-48122 | biostudies-arrayexpress
TranscriptomicsCGH analysis of haploid ES cells
DNA samples of haploid ES cells and control DNA were compared to genomic DNA of the C57B/6 inbred mouse strain on a NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array (Build MM9), (GPL10989) this analysis was performed to analyse copy number variations in haploid mouse ES cells from different gene...
ORGANISM(S): Mus musculus 
2011-07-22 | E-GEOD-30749 | biostudies-arrayexpress
TranscriptomicsExpression analysis of haploid and diploid ES cells in 2i medium
gene expression differences were analysed between haploid and diploid ES cells biological triplicates of haploid and diploid ES cell lines were analysed on an Affymetrix GeneChip 430 array
ORGANISM(S): Mus musculus 
2011-07-22 | E-GEOD-30744 | biostudies-arrayexpress
ProteomicsPhosphorylation of the transcriptional-corepressor SPEN in naïve mouse embryonic stem cells and under artificial induction of X chromosome inactivation
We developed a CRISPR/Cas9-mediated base-editing screen to functionally screen endogenous proteins. We screened SPEN, a key factor in X chromosome inactivation, for loss-of-function mutations. Some of the screen hits were mutations of serine residues that could be potential phosphorylation sites (by...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-08 | PXD073932 | Pride
Spen Xci Dosage compensation X chromosome Idr Gene regulation Timstof Phosphoproteomics Xist 
UnknownEpigenetic regulation limits competence of pluripotent stem cell-derived oocytes
Not available
S-SCDT-10_15252-EMBJ_2023113955 | biostudies-other
UnknownHomologous recombination is reduced in female embryonic stem cells by two active X chromosomes
Not available
S-SCDT-EMBOR-2020-52190V1 | biostudies-other
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