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UnknownEmerging insights into inflammatory bowel disease from the intestinal microbiota perspective: a bibliometric analysis.
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S-EPMC10639163 | biostudies-literature
TranscriptomicsCrohn's disease risk variant in GPR65 alters lysosomal function
Using an siRNA screen we identify a role for GPR65 in the defense against intracellular pathogens. Epithelial cells and macrophages lacking GPR65 exhibited impaired clearance of intracellular bacteria as well as an accumulation of aberrant phagosomes and lysosomes. Transcriptional profiling revealed...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-69445 | biostudies-arrayexpress
TranscriptomicsIntegrated genomics of Crohn’s disease risk variant identifies a role for CLEC12A in antibacterial autophagy
Using integrated genomics we identify a role for CLEC12A in antibacterial autophagy. Clec12a-/- mice are more susceptible to bacterial infection and CLEC12A deficient cells exhibit impaired antibacterial autophagy. We used transcriptional profilinf to understand the role of CLEC12A in the response t...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-69132 | biostudies-arrayexpress
TranscriptomicsAnalysis of bacterial and macrophage transcripts in ISRE-positive and negative infected macrophages
To identify bacterial transcripts that may be associated with type I IFN production in Salmonella enterica subsp typhimurium (SL1344) infected macrophages we transformed macrophages with an ISRE-GFP reporter construct and sorted separate populations of GFP positive and GFP negative infected macropha...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65531 | biostudies-arrayexpress
TranscriptomicsThe kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells [array]
Using an unbiased chemical biology approach, we discover harmine as a novel regulator of Treg/Th17 differentiation. Harmine enhances Treg differentiation (working in conjunction with low levels of exogenous TGFb) and inhibits Th17 differentiation. Analysis of global gene expression of Tregs generate...
ORGANISM(S): Mus musculus 
2015-04-29 | E-GEOD-64247 | biostudies-arrayexpress
TranscriptomicsSingle cell analysis of macrophages exposed to beads coated with LPS from Salmonella enterica subsp. typhimurium
We present a detailed single cell analysis of the macrophage response to LPS from Salmonella enterica. By combining single cell transcriptional analysis, fluorescently labeled, LPS-coated beads, and cytometry we are able to distinguish the responses of macrophages that have internalized LPS-coated ...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65529 | biostudies-arrayexpress
TranscriptomicsSingle cell time course of macrophages exposed to Salmonella enterica subsp. typhimurium
We present a detailed single cell time course of the macrophage response to Salmonella infection. By combining phenotypic fluorescent labels with single cell expression analysis we are able to identify gene modules associated with bacterial exposure and bacterial infection. We also identify other ...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65528 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq analysis of the macrophage response to Salmonella enterica subsp. Typhimurium (SL1344) exposure
A time course of the macrophage response to Salmonella exposure analyzing the effects of input cell number as a control for single cell studies Mouse macrophages were exposed to Salmonella enterica for different lengths of time. Libraries were constructed using either approximately 500,00 macrophag...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65530 | biostudies-arrayexpress
MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
ProteomicsGut Microbial Ecosystem Multiomics in Inflammatory Bowel Disease
Using multiple omics approaches to explore the effect of the gut microbial ecosytem on inflammatory bowel disease
ORGANISM(S): Environmental Samples <bacteria> (ncbitaxon:48479) 
2019-07-02 | MSV000084050 | MassIVE
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